Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung.

Journal: Journal of biomedical semantics
Published Date: Oct 24, 2019

Abstract

BACKGROUND: Although the mouse is widely used to model human lung development, function, and disease, our understanding of the molecular mechanisms involved in alveolarization of the peripheral lung is incomplete. Recently, the Molecular Atlas of Lung Development Program (LungMAP) was funded by the National Heart, Lung, and Blood Institute to develop an integrated open access database (known as BREATH) to characterize the molecular and cellular anatomy of the developing lung. To support this effort, we designed detailed anatomic and cellular ontologies describing alveolar formation and maturation in both mouse and human lung.

Authors

  • Huaqin Pan
    BioInformatics, Research Computing Division, RTI International, 3020 Cornwallis Road, Research Triangle Park, Raleigh, North Carolina, 27709, USA.
  • Gail H Deutsch
    Department of Pathology, Seattle Children's Hospital, University of Washington School of Medicine, 4800 Sand Point Way NE, Seattle, Washington, 98105, USA.
  • Susan E Wert
    Department of Pediatrics, Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center/Research Foundation, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC7029, Cincinnati, OH, 45229, USA. susan.wert@cchmc.org.

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