Joint optic disc and cup segmentation using semi-supervised conditional GANs.

Journal: Computers in biology and medicine
Published Date:

Abstract

Glaucoma is a chronic and widespread eye disease threatening humans' irreversible vision loss. The cup-to-disc ratio (CDR), one of the most important measurements used for glaucoma screening and diagnosis, requires accurate segmentation of optic disc and cup from fundus images. However, most existing techniques fail to obtain satisfactory segmentation performance because a significant number of pixel-level annotated data are often unavailable during training. To cope with this limitation, in this paper, we propose an effective joint optic disc and cup segmentation method based on semi-supervised conditional Generative Adversarial Nets (GANs). Our architecture consists of a segmentation net, a generator and a discriminator, to learn a mapping between the fundus images and the corresponding segmentation maps. Additionally, we employ both labeled and unlabeled data to improve the segmentation performance. The extensive experiments show that our method achieves state-of-the-art optic disc and cup segmentation results on both ORIGA and REFUGE datasets.

Authors

  • Shaopeng Liu
    Department of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, 510006, China; Guangdong Key Laboratory of Big Data Analysis and Processing, Guangzhou, 510006, China.
  • Jiaming Hong
    School of Medical Information Engineering, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
  • Xu Lu
    Department of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, 510006, China. Electronic address: bruda@126.com.
  • Xiping Jia
    Department of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, 510006, China.
  • Zhiyong Lin
    Department of Computer Science, Guangdong Polytechnic Normal University, Guangzhou, 510006, China.
  • Ying Zhou
    Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
  • Ye Liu
    Department of Cell Biology, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, USA.
  • Heye Zhang
    School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, China.