Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells.

Journal: Journal of advanced research
PMID: 35777918

Abstract

INTRODUCTION: The regenerative capacity of mesenchymal stromal cells or medicinal signaling cells (MSCs) is largely mediated by their secreted small extracellular vesicles (sEVs), and the therapeutic efficacy of sEVs can be enhanced by licensing approaches (e.g., cytokines, hypoxia, chemicals, and genetic modification). Noncoding RNAs within MSC-derived sEVs (MSC-sEVs) have been demonstrated to be responsible for tissue regeneration. However, unlike miRNA fingerprints, which have been explored, the landscape of long noncoding RNAs (lncRNAs) in MSC-sEVs remains to be described.

Authors

  • Chien-Wei Lee
    Department of Medicine Research, China Medical University Hospital, Taichung, Taiwan; Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Yi-Fan Chen
    The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11529, Taiwan; Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, 11031 Taipei, Taiwan; International Ph.D. Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, 11031 Taipei, Taiwan; Master Program in Clinical Genomics and Proteomics, School of Pharmacy, Taipei Medical University, Taipei, 11031, Taiwan.
  • Allen Wei-Ting Hsiao
    Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Amanda Yu-Fan Wang
    Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Oscar Yuan-Jie Shen
    Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Belle Yu-Hsuan Wang
    Department of Orthopaedics and Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Lok Wai Cola Ho
    Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Wei-Ting Lin
    Doctoral Degree Program of Translational Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taiwan.
  • Chung Hang Jonathan Choi
    Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong; School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.
  • Oscar Kuang-Sheng Lee
    Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan. Electronic address: oscarlee9203@gmail.com.

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