Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment. We investigated differences in the surface proteome...
Endometrial cancer (EC) molecular subtyping is critical for prognosis and treatment but remains hindered by reliance on invasive tissue biopsies and time-consuming genomic sequencing. Here, we present a minimally invasive approach integrating MALDI-T...
Hepatocellular carcinoma (HCC) is a leading cause of global cancer-related mortality, with delayed diagnosis adversely affecting patient outcomes. Liquid biopsy techniques using small extracellular vesicles (EVs) offer potential for cancer detection,...
Heterogeneity in cancer is known to be a contributor to the formation of metastatic lesions, poor prognosis, and ultimately undermines therapeutic efficacy. This same tumor heterogeneity is reflected in circulating tumor cells (CTCs) and tumor derive...
Gastric cancer (GC) continues to pose a significant global health burden with persistent diagnostic challenges, especially in the detection of early-stage GC. Herein, a strand displacement reaction-mediated nucleic acid amplifier based on the spatial...
Membrane curvature is a key biophysical feature that regulates diverse biological processes. A wide range of natural proteins have distinct structural motifs that can sense membrane curvature and function independently as curvature-sensing peptides. ...
Small extracellular vesicles (sEVs) are nanoscale vesicles carrying biomolecules reflective of their cellular origin, making them attractive biomarkers for cancer diagnosis. In this study, we present a high-throughput strategy integrating amphiphile-...
In early cancer diagnosis, extracellular vesicles (EVs) are more advantageous than circulating tumor cells due to their smaller size, greater stability, and enhanced tissue penetration. These qualities lead to higher EV concentrations in body fluids,...
Chemical communications (Cambridge, England)
Sep 11, 2025
Extracellular vesicles are lipid bilayer-enclosed nanoparticles that play a crucial role in intercellular communication by transporting bioactive molecules across cells, tissues, and even organisms. Although certain aspects of EV biogenesis, function...
Extracellular vesicles (EVs) have emerged as promising biomarkers in cancer diagnostics. However, rapid and nondestructive isolation of EVs from plasma remains challenging due to the presence of abundant interferents with smaller sizes (e.g., protein...
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