AIMC Topic: Extracellular Vesicles

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Determination of miRNA in tear extracellular vesicles significantly associated with treatment-requiring retinopathy of prematurity: a pilot study.

Scientific reports
Retinopathy of prematurity (ROP) develops in some premature infants and may be characterized by permanent severe retinal damage necessitating early detection and prompt treatment. The purpose of this study was to investigate whether specific miRNAs i...

Human multiethnic radiogenomics reveals low-abundancy microRNA signature in plasma-derived extracellular vesicles for early diagnosis and molecular subtyping of pancreatic cancer.

eLife
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...

"Small extracellular vesicles: messengers at the service of breast cancer agenda in the primary and distant microenvironments".

Journal of experimental & clinical cancer research : CR
Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with complex mechanisms driving its initiation, progression, and resistance to therapy. In recent years, the tumor microenvironment (TME) has gained attention for its cr...

Nanozyme-Enabled Multimodal Sensing: Visual and Rapid Profiling of Extracellular Vesicles.

Analytical chemistry
CD20, a transmembrane protein on the surface of lymphoma extracellular vesicles (EVs), is highly expressed and serves as an effective marker for monitoring lymphoma subtypes and evaluating the efficacy of antibody therapy. Therefore, there is an urge...

Deep Learning-Based Classification of NSCLC-Derived Extracellular Vesicles Using AFM Nanomechanical Signatures.

Analytical chemistry
Nonsmall cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with liquid biopsy emerging as a promising tool for noninvasive diagnostics. Extracellular vesicles (EVs) serve as molecular messengers of the tumor microenvironme...

5-Hydroxymethylcytosine signatures as diagnostic biomarkers for septic cardiomyopathy.

Scientific reports
At present, there are currently no molecular biomarkers for the early diagnosis of sepsis cardiomyopathy (SCM) in clinical practice. This study focuses on an in-depth examination of the DNA hydroxymethylation profiles within plasma extracellular vesi...

Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome.

Nature communications
Extracellular vesicles (EVs) in plasma are composed of exosomes, microvesicles, and apoptotic bodies. We report a plasma EV enrichment strategy using magnetic beads called Mag-Net. Proteomic interrogation of this plasma EV fraction enables the detect...

Simple and Rapid Tumor EV Enrichment Enabled by Long DNA Probe-Guided Entanglement.

Angewandte Chemie (International ed. in English)
Specific subpopulations of extracellular vesicles (EVs) hold significant clinical potential for biomarker discovery, disease diagnosis, and therapeutic agents. However, this field remains underutilized due to the lack of straightforward and versatile...

Lipidomic profiling of human adiposomes identifies specific lipid shifts linked to obesity and cardiometabolic risk.

JCI insight
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate obesity-rela...

Insight into microbial extracellular vesicles as key communication materials and their clinical implications for lung cancer (Review).

International journal of molecular medicine
The complexity of lung cancer, driven by multifactorial causes such as genetic, environmental and lifestyle factors, underscores the necessity for tailored treatment strategies informed by recent advancements. Studies highlight a significant associat...