A generative model for constructing nucleic acid sequences binding to a protein.
Journal:
BMC genomics
PMID:
31881936
Abstract
BACKGROUND: Interactions between protein and nucleic acid molecules are essential to a variety of cellular processes. A large amount of interaction data generated by high-throughput technologies have triggered the development of several computational methods either to predict binding sites in a sequence or to determine whether a pair of sequences interacts or not. Most of these methods treat the problem of the interaction of nucleic acids with proteins as a classification problem rather than a generation problem.