AIMC Topic: Aptamers, Nucleotide

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Lateral flow and colorimetric assay for ketamine detection reinforced with deep learning model interfaced with mobile app for smart alert.

Mikrochimica acta
Point-of-care (POC) devices have grown in popularity due to their ease of use, low cost, and speedy on-site diagnostic capabilities. This study focuses on ketamine detection by colorimetric and lateral flow assays (LFA), with aptamer-based LFA emergi...

Dual-Mode SERS Lateral Flow Aptamer Assay with Machine Learning-Driven Highly Sensitive Interferon-γ Detection.

ACS synthetic biology
Interferon-γ (IFN-γ), a key pro-inflammatory cytokine, is widely recognized as a critical biomarker for diagnosing and monitoring various immune-related conditions. However, its typically low concentrations in biological fluids─at the picogram-per-mi...

Antifouling Capture and Dual-Targeting Recognition-Induced Signal Amplification for Triple-Mode Detection and Identification of Circulating Tumor Cells.

Analytical chemistry
Circulating tumor cells (CTCs) are promising biomarkers for cancer diagnosis, while detecting CTCs in clinical samples is still challenging due to the scarcity and heterogeneity of CTCs. Herein, a triple-mode sensing platform based on an antifouling ...

Aptasensing Technology and Its Potential Applications: Where Do We Stand?

Molecular pharmaceutics
Aptamers, valued for their stability, target affinity, and modifiability, have advanced biosensing, yet key challenges hinder their translation into practical sensing platforms. This work explores the future potential of aptasensing technologies acro...

Aptamer-functionalized graphene quantum dots combined with artificial intelligence detect bacteria for urinary tract infections.

Frontiers in cellular and infection microbiology
OBJECTIVES: Urinary tract infection is one of the most prevalent forms of bacterial infection, and prompt and efficient identification of pathogenic bacteria plays a pivotal role in the management of urinary tract infections. In this study, we propos...

Ratiometric, 3D Fluorescence Spectrum with Abundant Information for Tetracyclines Discrimination via Dual Biomolecules Recognition and Deep Learning.

Analytical chemistry
Tetracyclines are widely used in bacteria infection treatment, while the subtle chemical differences between tetracyclines make it a challenge to accurate discrimination via biosensors. A 3D fluorescence spectrum can provide fingerprint structure inf...

Comparative Analysis of Machine Learning Algorithms Used for Translating Aptamer-Antigen Binding Kinetic Profiles to Diagnostic Decisions.

ACS sensors
Current approaches for classifying biosensor data in diagnostics rely on fixed decision thresholds based on receiver operating characteristic (ROC) curves, which can be limited in accuracy for complex and variable signals. To address these limitation...

Deep Learning-Assisted Fluorescence Single-Particle Detection of Fumonisin B Powered by Entropy-Driven Catalysis and Argonaute.

Analytical chemistry
Timely and accurate detection of trace mycotoxins in agricultural products and food is significant for ensuring food safety and public health. Herein, a deep learning-assisted and entropy-driven catalysis (EDC)-Argonaute powered fluorescence single-p...

Colorimetric aptasensor coupled with a deep-learning-powered smartphone app for programmed death ligand-1 expressing extracellular vesicles.

Frontiers in immunology
Lung cancer is a devastating public health threat and a leading cause of cancer-related deaths. Therefore, it is imperative to develop sophisticated techniques for the non-invasive detection of lung cancer. Extracellular vesicles expressing programme...

Microfluidic Optical Aptasensor for Small Molecules Based on Analyte-Tuned Growth of Gold Nanoseeds and Machine Learning-Enhanced Spectrum Analysis: Rapid Detection of Mycotoxins.

ACS sensors
Natural toxins, mainly small molecules, are a category of chemical hazards in agri-food systems that pose threats to both public health and food security. Current standard methods for monitoring these toxins, predominantly based on liquid chromatogra...