AIMC Topic: Transcription Factors
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Non-coding genetic elements of lung cancer identified using whole genome sequencing in 13,722 Chinese.
Nature communications
Aug 9, 2025
A substantial portion of lung cancer-associated genetic elements in East Asian populations remains unidentified, underscoring the need for large-scale genome-wide studies, particularly on non-coding regulation. We conducted a whole genome sequencing ...
Deep learning-based high-resolution time inference for deciphering dynamic gene regulation from fixed embryos.
Nature communications
Jul 16, 2025
Embryo development is driven by the spatiotemporal dynamics of complex gene regulatory networks. Uncovering these dynamics requires simultaneous tracking of multiple fluctuating molecular species over time, which exceeds the capabilities of tradition...
A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma.
Scientific reports
Jul 13, 2025
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecular subtype...
Gene Expression Profiling
Protein Interaction Maps
Gene Regulatory Networks
Gene Expression Regulation, Neoplastic
Humans
Prognosis
Biomarkers, Tumor
Brain Neoplasms
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Mutation
Transcription Factors
Glioma
Basic Helix-Loop-Helix Transcription Factors
Identification of diagnostic biomarkers and dissecting immune microenvironment with crosstalk genes in the POAG and COVID-19 nexus.
Scientific reports
Jul 12, 2025
An underlying association between primary open-angle glaucoma (POAG) and COVID-19 has been hypothesized, but the causal link and shared mechanisms remain unclear. This study integrates epidemiological and bioinformatics approaches to investigate thei...
TRIM29 alleviates intervertebral disc degeneration through the PI3K/AKT/mTOR pathway.
Scientific reports
Jul 10, 2025
Intervertebral disc degeneration (IDD), a prevalent spinal condition linked to low back pain, has substantial genetic components, necessitating deeper understanding of its mechanisms. This study categorized nucleus pulposus cell (NPC) populations and...
Identifying propionate metabolism-related genes as biomarkers of sepsis development and therapeutic targets.
Scientific reports
Jul 8, 2025
The treatment of sepsis is challenging due to unclear mechanisms. Propionate is increasingly seen as critical to sepsis pathophysiology by bridging gut microbiota and immunity, but the mechanisms remain unclear. Our study analysed differences in prop...
Dissecting crosstalk induced by cell-cell communication using single-cell transcriptomic data.
Nature communications
Jul 1, 2025
During cell-cell communication (CCC), pathways activated by different ligand-receptor pairs may have crosstalk with each other. While multiple methods have been developed to infer CCC networks and their downstream response using single-cell RNA-seq d...
Divergence in a eukaryotic transcription factor's co-TF dependence involves multiple intrinsically disordered regions.
Nature communications
Jun 18, 2025
Combinatorial control by transcription factors (TFs) is central to eukaryotic gene regulation, yet its mechanism, evolution, and regulatory impact are not well understood. Here we use natural variation in the yeast phosphate starvation (PHO) response...
Combinatorial discovery of microtopographical landscapes that resist biofilm formation through quorum sensing mediated autolubrication.
Nature communications
Jun 18, 2025
Bio-instructive materials that intrinsically inhibit biofilm formation have significant anti-biofouling potential in industrial and healthcare settings. Since bacterial surface attachment is sensitive to surface topography, we experimentally surveyed...
A library of lineage-specific driver lines connects developing neuronal circuits to behavior in the ventral nerve cord.
eLife
Jun 10, 2025
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due t...
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