iRNAD: a computational tool for identifying D modification sites in RNA sequence.

Journal: Bioinformatics (Oxford, England)
Published Date: Dec 1, 2019

Abstract

MOTIVATION: Dihydrouridine (D) is a common RNA post-transcriptional modification found in eukaryotes, bacteria and a few archaea. The modification can promote the conformational flexibility of individual nucleotide bases. And its levels are increased in cancerous tissues. Therefore, it is necessary to detect D in RNA for further understanding its functional roles. Since wet-experimental techniques for the aim are time-consuming and laborious, it is urgent to develop computational models to identify D modification sites in RNA.

Authors

  • Zhao-Chun Xu
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen, China.
  • Peng-Mian Feng
    Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan 063000, China. fengpengmian@gmail.com.
  • Hui Yang
    Department of Neurology, The Second Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang, China.
  • Wang-Ren Qiu
    Computer Department, Jingdezhen Ceramic Institute, Jingdezhen, 333403, China; Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology and Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: qiuone@163.com.
  • Wei Chen
    Department of Urology, Zigong Fourth People's Hospital, Sichuan, China.
  • Hao Lin
    Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou, Zhejiang, China.

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