Heterogeneity of executive function revealed by a functional random forest approach across ADHD and ASD.

Journal: NeuroImage. Clinical
PMID: 32217469

Abstract

BACKGROUND: Those with autism spectrum disorder (ASD) and/or attention-deficit-hyperactivity disorder (ADHD) exhibit symptoms of hyperactivity and inattention, causing significant hardships for families and society. A potential mechanism involved in these conditions is atypical executive function (EF). Inconsistent findings highlight that EF features may be shared or distinct across ADHD and ASD. With ADHD and ASD each also being heterogeneous, we hypothesized that there may be nested subgroups across disorders with shared or unique underlying mechanisms.

Authors

  • Michaela Cordova
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: cordova@ohsu.edu.
  • Kiryl Shada
    Division of Developmental/Behavioral Pediatrics and Psychology; Rainbow Babies & Children's Hospital, 11100 Euclid Ave., Cleveland, OH 44106, USA. Electronic address: Kiryl.Shada@UHhospitals.org.
  • Damion V Demeter
    Department of Psychology; U. Texas Austin, Austin, TX; University of Texas at Austin, 108 E Dean Keeton St., Austin, TX 78712, USA. Electronic address: demeter@utexas.edu.
  • Olivia Doyle
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: doyleo@ohsu.edu.
  • Oscar Miranda-Dominguez
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: mirandad@ohsu.edu.
  • Anders Perrone
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: perronea@ohsu.edu.
  • Emma Schifsky
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA.
  • Alice Graham
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA; Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: grahaal@ohsu.edu.
  • Eric Fombonne
    Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: fombonne@ohsu.edu.
  • Beth Langhorst
    Center for Spoken Language Understanding, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: calame@ohsu.edu.
  • Joel Nigg
    Department of Psychiatry, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: niggj@ohsu.edu.
  • Damien A Fair
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA; Advanced Imaging Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: faird@ohsu.edu.
  • Eric Feczko
    Department of Behavioral Neuroscience, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA; Department of Medical Informatics and Clinical Epidemiology; Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97221, USA. Electronic address: feczko@ohsu.edu.

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