Medi-Care AI: Predicting medications from billing codes via robust recurrent neural networks.

Journal: Neural networks : the official journal of the International Neural Network Society
Published Date:

Abstract

In this paper, we present an effective deep prediction framework based on robust recurrent neural networks (RNNs) to predict the likely therapeutic classes of medications a patient is taking, given a sequence of diagnostic billing codes in their record. Accurately capturing the list of medications currently taken by a given patient is extremely challenging due to undefined errors and omissions. We present a general robust framework that explicitly models the possible contamination through overtime decay mechanism on the input billing codes and noise injection into the recurrent hidden states, respectively. By doing this, billing codes are reformulated into its temporal patterns with decay rates on each medical variable, and the hidden states of RNNs are regularized by random noises which serve as dropout to improved RNNs robustness towards data variability in terms of missing values and multiple errors. The proposed method is extensively evaluated on real health care data to demonstrate its effectiveness in suggesting medication orders from contaminated values.

Authors

  • Deyin Liu
    School of Information Engineering, Zhengzhou University, China. Electronic address: iedyzzu@outlook.com.
  • Yuanbo Lin Wu
    Key Laboratory of Knowledge Engineering with Big Data (Hefei University of Technology), Ministry of Education, China; School of Computer Science and Information Engineering, Hefei University of Technology, Hefei 230000, China. Electronic address: xiaoxian.wu9188@gmail.com.
  • Xue Li
    Department of Clinical Research Center, Dazhou Central Hospital, Dazhou 635000, China.
  • Lin Qi
    a Sino-Dutch Biomedical and Information Engineering School , Northeastern University , Shenyang , Liaoning , China.