Classification and Prognosis Prediction from Histopathological Images of Hepatocellular Carcinoma by a Fully Automated Pipeline Based on Machine Learning.

Journal: Annals of surgical oncology
Published Date:

Abstract

OBJECTIVE: The aim of this study was to develop quantitative feature-based models from histopathological images to distinguish hepatocellular carcinoma (HCC) from adjacent normal tissue and predict the prognosis of HCC patients after surgical resection.

Authors

  • Haotian Liao
    Department of Liver Surgery and Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
  • Tianyuan Xiong
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
  • Jiajie Peng
    School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China. jiajiepeng@hit.edu.cn.
  • Lin Xu
    Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University Chengdu 610039 China xingyage1@163.com.
  • Mingheng Liao
    Department of Liver Surgery and Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
  • Zhen Zhang
    School of Pharmacy, Jining Medical University, Rizhao, Shandong, China.
  • Zhenru Wu
    Laboratory of Pathology, Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
  • Kefei Yuan
    Department of Liver Surgery and Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China. ykf13@163.com.
  • Yong Zeng
    a College of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , P.R. China.