Development of Expert-Level Automated Detection of Epileptiform Discharges During Electroencephalogram Interpretation.

Journal: JAMA neurology
Published Date: Jan 1, 2020

Abstract

IMPORTANCE: Interictal epileptiform discharges (IEDs) in electroencephalograms (EEGs) are a biomarker of epilepsy, seizure risk, and clinical decline. However, there is a scarcity of experts qualified to interpret EEG results. Prior attempts to automate IED detection have been limited by small samples and have not demonstrated expert-level performance. There is a need for a validated automated method to detect IEDs with expert-level reliability.

Authors

  • Jin Jing
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
  • Haoqi Sun
    Neurology Department, Massachusetts General Hospital, Wang 720, Boston, MA, USA.
  • Jennifer A Kim
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Aline Herlopian
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.
  • Ioannis Karakis
    Department of Neurology, School of Medicine, Emory University, Atlanta, GA, United States.
  • Marcus Ng
    Department of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Jonathan J Halford
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina.
  • Douglas Maus
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Fonda Chan
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Marjan Dolatshahi
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Carlos Muniz
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Catherine Chu
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Valeria Sacca
    Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.
  • Jay Pathmanathan
    Department of Neurology, University of Pennsylvania General Hospital, Boston, Massachusetts.
  • Wendong Ge
    Brigham and Women's Hospital.
  • Justin Dauwels
    School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
  • Alice Lam
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Andrew J Cole
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.
  • Sydney S Cash
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • M Brandon Westover
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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