Plus Disease in Retinopathy of Prematurity: Convolutional Neural Network Performance Using a Combined Neural Network and Feature Extraction Approach.

Journal: Translational vision science & technology
PMID: 32704416

Abstract

PURPOSE: Retinopathy of prematurity (ROP), a leading cause of childhood blindness, is diagnosed by clinical ophthalmoscopic examinations or reading retinal images. Plus disease, defined as abnormal tortuosity and dilation of the posterior retinal blood vessels, is the most important feature to determine treatment-requiring ROP. We aimed to create a complete, publicly available and feature-extraction-based pipeline, I-ROP ASSIST, that achieves convolutional neural network (CNN)-like performance when diagnosing plus disease from retinal images.

Authors

  • Veysi M Yildiz
    Cognitive Systems Laboratory, Northeastern University, Boston, MA, USA.
  • Peng Tian
    Department of Electrical and Computer Engineering, Northeastern University, 360 Huntington Avenue, 409 Dana, Boston, MA 02115, USA. Electronic address: pengtian@ece.neu.edu.
  • Ilkay Yildiz
    Cognitive Systems Laboratory, Northeastern University, Boston, MA, USA.
  • James M Brown
    Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH/Harvard Medical School, Charlestown, MA, United States.
  • Jayashree Kalpathy-Cramer
    Department of Radiology, MGH/Harvard Medical School, Charlestown, Massachusetts.
  • Jennifer Dy
    Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts.
  • Stratis Ioannidis
    Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts.
  • Deniz Erdogmus
    Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts.
  • Susan Ostmo
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Sang Jin Kim
    Ophthalmology Oregon Health & Science University, Portland, OR, United States.
  • R V Paul Chan
    Ophthalmology, Illinois Eye and Ear Infirmary, Chicago, IL, United States.
  • J Peter Campbell
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Michael F Chiang
    National Eye Institute, National Institutes of Health, Bethesda, Maryland.

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