Lipidome-based rapid diagnosis with machine learning for detection of TGF-β signalling activated area in head and neck cancer.

Journal: British journal of cancer
PMID: 32020064

Abstract

BACKGROUND: Several pro-oncogenic signals, including transforming growth factor beta (TGF-β) signalling from tumour microenvironment, generate intratumoural phenotypic heterogeneity and result in tumour progression and treatment failure. However, the precise diagnosis for tumour areas containing subclones with cytokine-induced malignant properties remains clinically challenging.

Authors

  • Hiroki Ishii
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan. Electronic address: ishiih@yamanashi.ac.jp.
  • Masao Saitoh
    Center for Medical Education and Sciences, Chuo-city, Japan.
  • Kaname Sakamoto
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Kei Sakamoto
    Section of Oral Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo City, Japan.
  • Daisuke Saigusa
    Department of Integrative Genomics, Tohoku University Tohoku Medical Megabank Organization, Sendai, Japan.
  • Hirotake Kasai
    Department of Microbiology, Chuo-city, Japan.
  • Kei Ashizawa
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Keiji Miyazawa
    Department of Biochemistry, Faculty of Medicine, University of Yamanashi, Chuo-city, Japan.
  • Sen Takeda
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. stakeda@yamanashi.ac.jp.
  • Keisuke Masuyama
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Yamanashi, Chuo-city, Yamanashi 409-3898, Japan.
  • Kentaro Yoshimura
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan. kyoshimura@yamanashi.ac.jp.

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