A Deep Learning Approach for Automated Sleep-Wake Scoring in Pre-Clinical Animal Models.

Journal: Journal of neuroscience methods
Published Date:

Abstract

BACKGROUND: Experimental investigation of sleep-wake dynamics in animals is an important part of pharmaceutical development. Typically, it involves recording of electroencephalogram, electromyogram, locomotor activity, and electrooculogram. Visual identification, or scoring, of the sleep-wake states from these recordings is time-consuming. We sought to develop software for automated sleep-wake scoring capable of processing large databases of multi-channel signal recordings in a range of species.

Authors

  • Vladimir Svetnik
    Biostatistics and Research Decision Sciences, Merck & Co., Inc., Rahway, NJ, United States.
  • Ting-Chuan Wang
    Merck & Co., Inc., Kenilworth, NJ, USA.
  • Yuting Xu
    Biostatistics and Research Decision Sciences, Merck & Co., Inc., Rahway, NJ, United States.
  • Bryan J Hansen
    Merck & Co., Inc., Kenilworth, NJ, USA.
  • Steven V Fox
    Merck & Co., Inc., Kenilworth, NJ, USA.