The Prognostic Significance of Quantitative Myocardial Perfusion: An Artificial Intelligence-Based Approach Using Perfusion Mapping.

Journal: Circulation
Published Date:

Abstract

BACKGROUND: Myocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR, the ratio of stress to rest MBF).

Authors

  • Kristopher D Knott
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Andreas Seraphim
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • João B Augusto
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Hui Xue
    Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
  • Liza Chacko
    Institute of Cardiovascular Science, University College London, United Kingdom (K.D.K., A.S., J.B.A., L.C., C.M., A.N.B., T.K., C.V.B., R.H.D., M.F., J.C.M.).
  • Nay Aung
    NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University, London, United Kingdom.
  • Steffen E Petersen
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
  • Jackie A Cooper
    William Harvey Research Institute, Queen Mary University of London, United Kingdom (N.A., S.E.P., J.A.C.).
  • Charlotte Manisty
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Anish N Bhuva
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Tushar Kotecha
    Institute of Cardiovascular Science, University College London, United Kingdom (K.D.K., A.S., J.B.A., L.C., C.M., A.N.B., T.K., C.V.B., R.H.D., M.F., J.C.M.).
  • Christos V Bourantas
    Institute of Cardiovascular Science, University College London, United Kingdom (K.D.K., A.S., J.B.A., L.C., C.M., A.N.B., T.K., C.V.B., R.H.D., M.F., J.C.M.).
  • Rhodri H Davies
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK.
  • Louise A E Brown
    Department of Biomedical Imaging Science, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (L.A.E.B., S.P.).
  • Sven Plein
    From the Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands (Q.T., E.H.M.P., D.P.S., A.d.R., H.J.L., R.J.v.d.G.); Department of Electrical Engineering, Fudan University, Shanghai, China (W.Y., Y.W.); Multidisciplinary Cardiovascular Research Centre & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, England (P.G., S.P.); Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (L.H., L.X.); and Departments of Cardiology (M.S.) and Radiology (J.T.), Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • Marianna Fontana
    Institute of Cardiovascular Science, University College London, United Kingdom (K.D.K., A.S., J.B.A., L.C., C.M., A.N.B., T.K., C.V.B., R.H.D., M.F., J.C.M.).
  • Peter Kellman
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (H.X., P.K.).
  • James C Moon
    Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, UK; Institute of Cardiovascular Science, University College London, London, UK. Electronic address: j.moon@ucl.ac.uk.