Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources.

Journal: Journal of the American Medical Informatics Association : JAMIA
PMID: 31769835

Abstract

OBJECTIVE: Real-world data (RWD) are increasingly used for pharmacoepidemiology and regulatory innovation. Our objective was to compare adverse drug event (ADE) rates determined from two RWD sources, electronic health records and administrative claims data, among children treated with drugs for pulmonary hypertension.

Authors

  • Alon Geva
    Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Steven H Abman
    Division of Pediatric Pulmonary Medicine, Children's Hospital Colorado, Aurora, Colorado, USA.
  • Shannon F Manzi
    Computational Health Informatics Program, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Dunbar D Ivy
    Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Mary P Mullen
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
  • John Griffin
    Division of Critical Care Medicine, Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Chen Lin
    Faculty of Business and Economics, University of Hong Kong, Hong Kong SAR 999077, China.
  • Guergana K Savova
    Department of Pediatrics, Children's Hospital of Boston, Boston.
  • Kenneth D Mandl
    Harvard Medical School, Boston, MA, USA.

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