Voice analysis in adductor spasmodic dysphonia: Objective diagnosis and response to botulinum toxin.

Journal: Parkinsonism & related disorders
PMID: 32222482

Abstract

INTRODUCTION: Adductor-type spasmodic dysphonia is a task-specific focal dystonia characterized by involuntary laryngeal muscle spasms. Due to the lack of quantitative instrumental tools, voice assessment in patients with adductor-type spasmodic dysphonia is mainly based on qualitative neurologic examination. We evaluated patients with cepstral analysis and specific machine-learning algorithms and compared the results with those collected in healthy subjects. In patients, we also used cepstral analysis and machine-learning algorithms to investigate the effect of botulinum neurotoxin type A.

Authors

  • Antonio Suppa
    Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed Institute, Pozzilli, IS, Italy.
  • Francesco Asci
    Department of Human Neurosciences, Sapienza University of Rome, Italy.
  • Giovanni Saggio
    Department of Electronic Engineering, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Luca Marsili
    Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.
  • Daniele Casali
    Department of Electronic Engineering, University of Rome Tor Vergata, Italy.
  • Zakarya Zarezadeh
    Department of History, Humanities and Society, University of Rome Tor Vergata, Italy.
  • Giovanni Ruoppolo
    Department of Sense Organs, Otorhinolaryngology Section, Sapienza University of Rome, Italy.
  • Alfredo Berardelli
    Department of Human Neurosciences, Sapienza University of Rome, Italy; IRCCS Neuromed Institute, Pozzilli, IS, Italy. Electronic address: alfredo.berardelli@uniroma1.it.
  • Giovanni Costantini
    Department of Electronic Engineering, University of Rome Tor Vergata, Italy.

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