AIMC Topic: Neuromuscular Agents

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Combined effects and timing of robotic training and botulinum toxin on upper limb spasticity and motor function: a single‑blinded randomized controlled pilot study.

Journal of neuroengineering and rehabilitation Mar 6, 2025
BACKGROUND: This study aimed to evaluate the combined effects of robotic training (RT) and botulinum toxin (BTX) injections on motor function and spasticity in individuals with post-stroke upper limb spasticity (ULS). We also sought to investigate th...
Adult Male Middle Aged Pilot Projects Treatment Outcome Humans Female Aged Upper Extremity Botulinum Toxins, Type A Neuromuscular Agents Stroke Rehabilitation Muscle Spasticity Botulinum Toxins Robotics Single-Blind Method Stroke Combined Modality Therapy Exercise Therapy
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External Validation Demonstrates Machine Learning Models Outperform Human Experts in Prediction of Objective and Patient-reported Overactive Bladder Treatment Outcomes.

Urology Sep 4, 2024
OBJECTIVE: To predict treatment response for overactive bladder (OAB) for a specific patient remains elusive. We sought to develop accurate models using machine learning for prediction of objective and patient-reported treatment response to intravesi...
Botulinum Toxins, Type A Neuromuscular Agents Humans Machine Learning Algorithms Female Aged Patient Reported Outcome Measures Administration, Intravesical Urinary Bladder, Overactive Male Middle Aged Treatment Outcome
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Feasibility of Adjunct Therapy with a Robotic Hand Orthosis after Botulinum Toxin Injections in Persons with Spasticity: A Pilot Study.

Toxins Aug 8, 2024
Upper-limb spasticity, frequent after central nervous system lesions, is typically treated with botulinum neurotoxin type A (BoNT-A) injections to reduce muscle tone and increase range of motion. However, performing adjunct physical therapy post-BoNT...
Adult Male Middle Aged Pilot Projects Treatment Outcome Humans Female Aged Neuromuscular Agents Muscle Spasticity Robotics Hand Feasibility Studies Orthotic Devices Botulinum Toxins, Type A
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Botulinum Toxin Type A (BoNT-A) Use for Post-Stroke Spasticity: A Multicenter Study Using Natural Language Processing and Machine Learning.

Toxins Aug 2, 2024
We conducted a multicenter and retrospective study to describe the use of botulinum toxin type A (BoNT-A) to treat post-stroke spasticity (PSS). Data were extracted from free-text in electronic health records (EHRs) in five Spanish hospitals. We incl...
Humans Machine Learning Retrospective Studies Electronic Health Records Natural Language Processing Stroke Botulinum Toxins, Type A Neuromuscular Agents Muscle Spasticity Female Aged Aged, 80 and over Male Middle Aged
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The Impact of Botulinum Toxin Combined with Robot-Assisted Gait Training on Spasticity and Gross Motor Function on Children with Spastic Cerebral Palsy.

Developmental neurorehabilitation Jun 13, 2024
OBJECTIVE: To evaluate the impact of combining botulinum toxin-A (BoNT-A) injection with robot-assisted gait training (RAGT) on lower limb spasticity and motor function in children with cerebral palsy.
Neuromuscular Agents Muscle Spasticity Female Male Child, Preschool Child Robotics Gait Combined Modality Therapy Exercise Therapy Cerebral Palsy Botulinum Toxins, Type A Humans Prospective Studies
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Voice analysis in adductor spasmodic dysphonia: Objective diagnosis and response to botulinum toxin.

Parkinsonism & related disorders Mar 19, 2020
INTRODUCTION: Adductor-type spasmodic dysphonia is a task-specific focal dystonia characterized by involuntary laryngeal muscle spasms. Due to the lack of quantitative instrumental tools, voice assessment in patients with adductor-type spasmodic dysp...
Humans Aged, 80 and over Adult Male Machine Learning Female Aged Botulinum Toxins, Type A Neuromuscular Agents Dysphonia Middle Aged Severity of Illness Index Treatment Outcome Speech Acoustics Fourier Analysis
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Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy.

IEEE transactions on haptics Aug 19, 2016
Abnormality of sensorimotor integration in the basal ganglia and cortex has been reported in the literature for patients with task-specific focal hand dystonia (FHD). In this study, we investigate the effect of manipulation of kinesthetic input in pe...
Feedback, Sensory Touch Perception Dystonic Disorders Kinesthesis Middle Aged Robotics Botulinum Toxins, Type A Neuromuscular Agents Self-Help Devices Humans Writing Female Aged Male
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Combined effects of robot‑assisted gait training and botulinum toxin type A on spastic equinus foot in patients with chronic stroke: a pilot, single blind, randomized controlled trial.

European journal of physical and rehabilitation medicine Apr 21, 2016
BACKGROUND: Despite the growing evidence about the use of robotic gait training in neurorehabilitation, there is a scant literature about the combined effects of this innovative technological approach and a first‑line treatment for focal spasticity a...
Robotics Single-Blind Method Humans Combined Modality Therapy Neuromuscular Agents Middle Aged Exercise Therapy Stroke Rehabilitation Pilot Projects Range of Motion, Articular Muscle Spasticity Treatment Outcome Chronic Disease Injections, Intramuscular Foot Botulinum Toxins, Type A
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Botulinum toxin injection in the pediatric population with medically refractory neuropathic bladder.

Journal of pediatric urology Oct 22, 2015
INTRODUCTION: Botulinum toxin injection (BTI) has been advocated as a second line therapy in management of neuropathic bladder in pediatric population for refractory patients to conventional medical management such as anticholinergics. The purpose wa...
Adolescent Follow-Up Studies Time Factors Administration, Intravesical Child, Preschool Child Urodynamics Treatment Outcome Botulinum Toxins, Type A Urinary Bladder, Neurogenic Neuromuscular Agents Humans Retrospective Studies Female Young Adult Male
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How could robotic training and botolinum toxin be combined in chronic post stroke upper limb spasticity? A pilot study.

European journal of physical and rehabilitation medicine Oct 31, 2014
BACKGROUND: Spasticity has a role of primary importance in functional motor recovery of upper limb after a stroke. The widespread intervention is the botulinum toxin neurolysis, however robotic training could have a role as useful addition to this co...
Quality of Life Pilot Projects Adolescent Time Factors Humans Treatment Outcome Upper Extremity Prospective Studies Aged, 80 and over Female Young Adult Aged Botulinum Toxins, Type A Adult Neuromuscular Agents Male Stroke Rehabilitation Middle Aged Muscle Spasticity Single-Blind Method Electromyography Follow-Up Studies Stroke Recovery of Function Exercise Therapy Chronic Disease Injections, Intramuscular Robotics Movement Disability Evaluation
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