Autonomous Biohybrid Urchin-Like Microperforator for Intracellular Payload Delivery.

Journal: Small (Weinheim an der Bergstrasse, Germany)
Published Date: Jun 1, 2020

Abstract

A magnetic urchin-like microswimmer based on sunflower pollen grain (SPG) that can pierce the cancer cell membrane and actively deliver therapeutic drugs is reported. These drug loaded microperforators are fabricated on a large scale by sequentially treating the natural SPGs with acidolysis, sputtering, and vacuum loading. The microswimmers exhibit precise autonomous navigation and obstacle avoidance in complex environments via association with artificial intelligence. Assemblies of microswimmers can further enhance individual motion performance and adaptability to complicated environments. Additionally, the experimental results demonstrate that microswimmers with nanospikes can accomplish single-cell perforation for direct delivery under an external rotating magnetic field. Drugs encapsulated in the inner cavity of the microperforators can be accurately delivered to a specific site via remote control. These dual-action microswimmers demonstrate good biocompatibility, high intelligence, precision in single-cell targeting, and sufficient drug loading, presenting a promising avenue for many varieties of biomedical applications.

Authors

  • Mengmeng Sun
  • Qi Liu
    National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Xinjian Fan
    State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, Harbin, 150001, China.
  • Yuefei Wang
    State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, Harbin, 150001, China.
  • Weinan Chen
    State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, Harbin, 150001, China.
  • Chenyao Tian
    State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, 2 Yikuang, Harbin, 150001, China.
  • Lining Sun
    School of Mechanical and Electronic Engineering, Soochow University, Suzhou, Jiangsu, China.
  • Hui Xie
    Department of Breast Diseases, The First Affiliated Hospital of Nanjing Medical University & Jiangsu Province Hospital, Nanjing, Jiangsu, China.

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