ColocML: machine learning quantifies co-localization between mass spectrometry images.

Journal: Bioinformatics (Oxford, England)
Published Date:

Abstract

MOTIVATION: Imaging mass spectrometry (imaging MS) is a prominent technique for capturing distributions of molecules in tissue sections. Various computational methods for imaging MS rely on quantifying spatial correlations between ion images, referred to as co-localization. However, no comprehensive evaluation of co-localization measures has ever been performed; this leads to arbitrary choices and hinders method development.

Authors

  • Katja Ovchinnikova
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
  • Lachlan Stuart
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
  • Alexander Rakhlin
    Neuromation OU, Tallinn, Estonia.
  • Sergey Nikolenko
    Kazan (Volga Region) Federal University, Kazan, Russia.
  • Theodore Alexandrov
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.