Use of Deep Learning to Develop and Analyze Computational Hematoxylin and Eosin Staining of Prostate Core Biopsy Images for Tumor Diagnosis.

Journal: JAMA network open
Published Date: May 1, 2020

Abstract

IMPORTANCE: Histopathological diagnoses of tumors from tissue biopsy after hematoxylin and eosin (H&E) dye staining is the criterion standard for oncological care, but H&E staining requires trained operators, dyes and reagents, and precious tissue samples that cannot be reused.

Authors

  • Aman Rana
  • Alarice Lowe
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Marie Lithgow
    Boston University School of Medicine, VA Boston Healthcare, West Roxbury, Massachusetts.
  • Katharine Horback
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Tyler Janovitz
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Annacarolina Da Silva
    Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Harrison Tsai
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Vignesh Shanmugam
    Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.
  • Akram Bayat
    Program in Media Arts and Sciences, Massachusetts Institute of Technology, Cambridge.
  • Pratik Shah

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