AIMC Topic: Hematoxylin

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Revealing 3D microanatomical structures of unlabeled thick cancer tissues using holotomography and virtual H&E staining.

Nature communications
In histopathology, acquiring subcellular-level three-dimensional (3D) tissue structures efficiently and without damaging the tissues during serial sectioning and staining remains a formidable challenge. We address this by integrating holotomography w...

Machine learning prediction of HER2-low expression in breast cancers based on hematoxylin-eosin-stained slides.

Breast cancer research : BCR
BACKGROUND: Treatment with HER2-targeted therapies is recommended for HER2-positive breast cancer patients with HER2 gene amplification or protein overexpression. Interestingly, recent clinical trials of novel HER2-targeted therapies demonstrated pro...

Multiple instance learning-based prediction of programmed death-ligand 1 (PD-L1) expression from hematoxylin and eosin (H&E)-stained histopathological images in breast cancer.

PeerJ
Programmed death-ligand 1 (PD-L1) is an important biomarker increasingly used as a predictive marker in breast cancer immunotherapy. Immunohistochemical quantification remains the standard method for assessment. However, it presents challenges relate...

ULST: U-shaped LeWin Spectral Transformer for virtual staining of pathological sections.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
At present, pathological section staining faces several challenges, including complex sample preparation and stringent infrastructure requirements. Virtual staining methods utilizing deep neural networks to automatically generate stained images are g...

Artificial intelligence-based virtual staining platform for identifying tumor-associated macrophages from hematoxylin and eosin-stained images.

European journal of cancer (Oxford, England : 1990)
BACKGROUND: Virtual staining is an artificial intelligence-based approach that transforms pathology images between stain types, such as hematoxylin and eosin (H&E) to immunohistochemistry (IHC), providing a tissue-preserving and efficient alternative...

Artificial intelligence challenge of discriminating cutaneous arteritis and polyarteritis nodosa based on hematoxylin-and-eosin images of skin biopsy specimens.

Pathology, research and practice
Diseases that develop necrotizing vasculitis of cutaneous muscular arteries include cutaneous arteritis (CA) and polyarteritis nodosa (PAN). It is difficult to distinguish them based on skin biopsy findings alone. This study demonstrated that artific...

Assessment of AI-based computational H&E staining versus chemical H&E staining for primary diagnosis in lymphomas: a brief interim report.

Journal of clinical pathology
Microscopic review of tissue sections is of foundational importance in pathology, yet the traditional chemistry-based histology laboratory methods are labour intensive, tissue destructive, poorly scalable to the evolving needs of precision medicine a...

Spatial transcriptome reveals histology-correlated immune signature learnt by deep learning attention mechanism on H&E-stained images for ovarian cancer prognosis.

Journal of translational medicine
BACKGROUND: The ability to predict the prognosis of patients with ovarian cancer can greatly improve disease management. However, the knowledge on the mechanism of the prediction is limited. We sought to deconvolute the attention feature learnt by a ...

Annotation-free deep learning algorithm trained on hematoxylin & eosin images predicts epithelial-to-mesenchymal transition phenotype and endocrine response in estrogen receptor-positive breast cancer.

Breast cancer research : BCR
Recent evidence indicates that endocrine resistance in estrogen receptor-positive (ER+) breast cancer is closely correlated with phenotypic characteristics of epithelial-to-mesenchymal transition (EMT). Nonetheless, identifying tumor tissues with a m...

HistoNeXt: dual-mechanism feature pyramid network for cell nuclear segmentation and classification.

BMC medical imaging
PURPOSE: To develop an end-to-end convolutional neural network model for analyzing hematoxylin and eosin(H&E)-stained histological images, enhancing the performance and efficiency of nuclear segmentation and classification within the digital patholog...