Generalization of deep learning models for ultra-low-count amyloid PET/MRI using transfer learning.

Journal: European journal of nuclear medicine and molecular imaging
Published Date:

Abstract

PURPOSE: We aimed to evaluate the performance of deep learning-based generalization of ultra-low-count amyloid PET/MRI enhancement when applied to studies acquired with different scanning hardware and protocols.

Authors

  • Kevin T Chen
    From the Departments of Radiology (K.T.C., F.B.d.C.M., S.S., G.Z.), Electrical Engineering (E.G., J.M.P.), and Neurology and Neurological Sciences (A.B., K.L.P., S.J.S., M.D.G., E.M.), Stanford University, 1201 Welch Rd, Stanford, CA 94305; Department of Engineering Physics, Tsinghua University, Beijing, PR China (J.X.); GE Healthcare, Menlo Park, Calif (M.K.); and Subtle Medical, Menlo Park, CA (E.G.).
  • Matti Schürer
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Jiahong Ouyang
    Stanford University, Stanford CA 94305, USA.
  • Mary Ellen I Koran
    Department of Radiology, Stanford University, Stanford, CA, United States.
  • Guido Davidzon
    Department of Radiology, Stanford University, Stanford, CA, United States.
  • Elizabeth Mormino
    From the Departments of Radiology (K.T.C., F.B.d.C.M., S.S., G.Z.), Electrical Engineering (E.G., J.M.P.), and Neurology and Neurological Sciences (A.B., K.L.P., S.J.S., M.D.G., E.M.), Stanford University, 1201 Welch Rd, Stanford, CA 94305; Department of Engineering Physics, Tsinghua University, Beijing, PR China (J.X.); GE Healthcare, Menlo Park, Calif (M.K.); and Subtle Medical, Menlo Park, CA (E.G.).
  • Solveig Tiepolt
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Karl-Titus Hoffmann
    Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
  • Osama Sabri
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Greg Zaharchuk
    Stanford University, Stanford CA 94305, USA.
  • Henryk Barthel
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.