Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the multicentre Italian CORIST Study.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD
PMID: 32912793

Abstract

BACKGROUND AND AIMS: There is poor knowledge on characteristics, comorbidities and laboratory measures associated with risk for adverse outcomes and in-hospital mortality in European Countries. We aimed at identifying baseline characteristics predisposing COVID-19 patients to in-hospital death.

Authors

  • Augusto Di Castelnuovo
    Mediterranea Cardiocentro, Napoli, Italy.
  • Marialaura Bonaccio
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
  • Simona Costanzo
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
  • Alessandro Gialluisi
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.
  • Andrea Antinori
    Clinical Department, National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Rome, Italy.
  • Nausicaa Berselli
    Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Lorenzo Blandi
    IRCCS Policlinico San Donato, San Donato Milanese, Italy.
  • Raffaele Bruno
    Division of Infectious Diseases I, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Clinical, Surgical, Diagnostic, and Paediatric Sciences, University of Pavia, Pavia, Italy.
  • Roberto Cauda
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
  • Giovanni Guaraldi
    Infectious Diseases Unit, Hospital Policlinico Modena, Department of Surgical and Medical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Ilaria My
    Humanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
  • Lorenzo Menicanti
    IRCCS Policlinico San Donato, San Donato Milanese, Italy.
  • Giustino Parruti
    Department of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
  • Giuseppe Patti
    Department of Thoracic, Heart and Vascular Diseases, Maggiore Della Carità Hospital, Corso Mazzini 18, 28100 Novara, Italy.
  • Stefano Perlini
    Emergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; Department of Internal Medicine, University of Pavia, Pavia, Italy.
  • Francesca Santilli
    Department of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
  • Carlo Signorelli
    School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Giulio G Stefanini
    Humanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
  • Alessandra Vergori
    HIV/AIDS Department, National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, Roma, Italy.
  • Amina Abdeddaim
    UOC Malattie Infettive-Epatologia, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
  • Walter Ageno
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Antonella Agodi
    Department of Medical and Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, AOU Policlinico "G. Rodolico - San Marco", Catania, Italy.
  • Piergiuseppe Agostoni
    Centro Cardiologico MonzinoScientific Institute for Research, Hospitalisation and Health Care (IRCCS)MilanItaly; Cardiovascular Section, Department of Clinical Sciences and Community HealthUniversity of MilanMilanItaly.
  • Luca Aiello
    UOC Anestesia e Rianimazione. Dipartimento di Chirurgia Generale Ospedale Morgagni-Pierantoni Forlì, Italy.
  • Samir Al Moghazi
    UOC Infezioni Sistemiche dell'Immunodepresso, National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
  • Filippo Aucella
    Fondazione I.R.C.C.S "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
  • Greta Barbieri
    Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
  • Alessandro Bartoloni
    Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
  • Carolina Bologna
    Ospedale del Mare, ASL NA1, Naples, Italy.
  • Paolo Bonfanti
    UOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
  • Serena Brancati
    Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
  • Francesco Cacciatore
    Department of Translational Medical Sciences. University of Naples, Federico II, Naples, Italy.
  • Lucia Caiano
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Francesco Cannata
    Humanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
  • Laura Carrozzi
    Cardiovascular and Thoracic Department, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
  • Antonio Cascio
    Infectious and Tropical Diseases Unit- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) - University of Palermo, Palermo, Italy.
  • Antonella Cingolani
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
  • Francesco Cipollone
    Department of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
  • Claudia Colomba
    Infectious and Tropical Diseases Unit- Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) - University of Palermo, Palermo, Italy.
  • Annalisa Crisetti
    Fondazione I.R.C.C.S "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Foggia, Italy.
  • Francesca Crosta
    Department of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
  • Gian B Danzi
    Department of Cardiology, Ospedale di Cremona, Cremona, Italy.
  • Damiano D'Ardes
    Department of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
  • Katleen de Gaetano Donati
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
  • Francesco Di Gennaro
    Medical Direction, IRCCS Neuromed, Pozzilli, IS, Italy.
  • Gisella Di Palma
    UOC Medicina - PO S. Maria di Loreto Nuovo -ASL Napoli 1 Centro, Napoli, Italy.
  • Giuseppe Di Tano
    Department of Cardiology, Ospedale di Cremona, Cremona, Italy.
  • Massimo Fantoni
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
  • Tommaso Filippini
    Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Paola Fioretto
    Clinica Medica 3, Department of Medicine - DIMED, University hospital of Padova, Padova, Italy.
  • Francesco M Fusco
    UOC Infezioni Sistemiche e dell'Immunodepresso, Azienda Ospedaliera dei Colli, Ospedale Cotugno, Napoli, Italy.
  • Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples "Federico II". Napoli, Italy.
  • Leonardo Grisafi
    University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.
  • Gabriella Guarnieri
    Respiratory Pathophysiology Division, Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
  • Francesco Landi
    UOC Anestesia e Rianimazione. Dipartimento di Chirurgia Generale Ospedale Morgagni-Pierantoni Forlì, Italy.
  • Giovanni Larizza
    COVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
  • Armando Leone
    UOC di Pneumologia, P.O. San Giuseppe Moscati, Taranto, Italy.
  • Gloria Maccagni
    Department of Cardiology, Ospedale di Cremona, Cremona, Italy.
  • Sandro Maccarella
    ASST Milano Nord - Ospedale Edoardo Bassini, Cinisello Balsamo, Italy.
  • Massimo Mapelli
    Centro Cardiologico Monzino IRCCS, Milano, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.
  • Riccardo Maragna
    Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milano, Milano, Italy.
  • Rossella Marcucci
    Department of Experimental and Clinical Medicine, University of Florence, Firenze, Italy.
  • Giulio Maresca
    Centro Cardiologico Monzino IRCCS, Milano, Italy; UOC Medicina - PO S. Maria di Loreto Nuovo -ASL Napoli 1 Centro, Napoli, Italy.
  • Claudia Marotta
    Medical Direction, IRCCS Neuromed, Pozzilli, IS, Italy.
  • Lorenzo Marra
    UOC di Pneumologia, P.O. San Giuseppe Moscati, Taranto, Italy.
  • Franco Mastroianni
    COVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
  • Alessandro Mengozzi
    Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
  • Francesco Menichetti
    Department of Clinical and Experimental Medicine, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
  • Jovana Milic
    Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Rita Murri
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore- Dipartimento di Sicurezza e Bioetica Sede di Roma, Italy.
  • Arturo Montineri
    U.O. C. Malattie Infettive e Tropicali, P.O. "San Marco", AOU Policlinico "G. Rodolico - San Marco", Catania, Italy.
  • Roberta Mussinelli
    Department of Internal Medicine, University of Pavia, Pavia, Italy.
  • Cristina Mussini
    Infectious Diseases Unit, Department of Surgical, Medical, Dental and Morphological Sciences, Azienda Ospedaliera-Universitaria of Modena, University of Modena and Reggio Emilia, Modena, Italy.
  • Maria Musso
    UOC Malattie Infettive-Apparato Respiratorio, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
  • Anna Odone
    School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; Clinical Epidemiology and HTA, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address: odone.anna@hsr.it.
  • Marco Olivieri
    Computer Service, University of Molise, Campobasso, Italy.
  • Emanuela Pasi
    Medicina Interna. Ospedale di Ravenna. AUSL della Romagna, Ravenna, Italy.
  • Francesco Petri
    UOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy.
  • Biagio Pinchera
    Department of Clinical Medicine and Surgery, University of Naples "Federico II". Napoli, Italy.
  • Carlo A Pivato
    Humanitas Clinical and Research Hospital IRCCS, Rozzano-Milano, Italy.
  • Roberto Pizzi
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Venerino Poletti
    UOC Pneumologia, Dipartimento di Malattie Apparato Respiratorio e Torace, Ospedale Morgagni-Pierantoni Forlì, Forlì, Italy.
  • Francesca Raffaelli
    Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
  • Claudia Ravaglia
    UOC Pneumologia, Dipartimento di Malattie Apparato Respiratorio e Torace, Ospedale Morgagni-Pierantoni Forlì, Forlì, Italy.
  • Giulia Righetti
    COVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
  • Andrea Rognoni
    Coronary Care Unit and Catheterization Laboratory, A.O.U. Maggiore della Carità, Novara, Italy.
  • Marco Rossato
    Clinica Medica 3, Department of Medicine - DIMED, University hospital of Padova, Padova, Italy.
  • Marianna Rossi
    UOC Malattie Infettive, Ospedale San Gerardo, ASST Monza, Monza, Italy.
  • Anna Sabena
    Emergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Francesco Salinaro
    Emergency Department, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
  • Vincenzo Sangiovanni
    UOC Infezioni Sistemiche e dell'Immunodepresso, Azienda Ospedaliera dei Colli, Ospedale Cotugno, Napoli, Italy.
  • Carlo Sanrocco
    Department of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
  • Antonio Scarafino
    COVID-19 Unit. EE Ospedale Regionale F. Miulli, Acquaviva delle Fonti, BA, Italy.
  • Laura Scorzolini
    UOC Malattie Infettive ad Alta Intensità di Cura, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
  • Raffaella Sgariglia
    ASST Milano Nord - Ospedale Edoardo Bassini, Cinisello Balsamo, Italy.
  • Paola G Simeone
    Department of Infectious Disease, Azienda Sanitaria Locale (AUSL) di Pescara, Pescara, Italy.
  • Enrico Spinoni
    University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy.
  • Carlo Torti
    Unit of Infectious and Tropical Diseases, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro, Italy.
  • Enrico M Trecarichi
    Infectious and Tropical Diseases Unit, Department of Medical and Surgical Sciences "Magna Graecia" University, Catanzaro, Italy.
  • Francesca Vezzani
    Department of Medicine and Aging, Clinica Medica, "SS. Annunziata" Hospital and University of Chieti, Chieti, Italy.
  • Giovanni Veronesi
    Department of Medicine and Surgery, University of Insubria, Varese, Italy.
  • Roberto Vettor
    Clinica Medica 3, Department of Medicine-DIMED, School of Medicine, University of Padua, Padua, Italy.
  • Andrea Vianello
    Respiratory Pathophysiology Division, Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
  • Marco Vinceti
  • Raffaele De Caterina
    Cardiovascular and Thoracic Department, Azienda Ospedaliero-Universitaria Pisana, and University of Pisa, Pisa, Italy.
  • Licia Iacoviello
    Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. Electronic address: licia.iacoviello@moli-sani.org.

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