Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Allergen immunotherapy (AIT) can induce immune tolerance to allergens by activating multiple mechanisms, including promoting IgG4 synthesis and blunting IgE production. However, the longitudinal data of sIgE and sIgG4 to allergen components during AIT are limited.

Authors

  • Lin Yang
    National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Yaqi Yang
    Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Qingxiu Xu
    Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Qing Jiang
    Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Wenjing Li
    Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Yin Wang
    State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China.
  • Dongxia Ma
    Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
  • Xiaomin Lin
    National Respiratory Medical Center, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
  • Baoqing Sun
    Department of Clinical Laboratory, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510120, China.
  • Rongfei Zhu
    Department of Allergy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.