AIMC Topic: Immunoglobulin E
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Identification of Hit Compounds Using Artificial Intelligence for the Management of Allergic Diseases.
International journal of molecular sciences
Feb 14, 2024
This study aimed to identify and evaluate drug candidates targeting the kinase inhibitory region of suppressor of cytokine signaling (SOCS) 3 for the treatment of allergic rhinitis (AR). Utilizing an artificial intelligence (AI)-based new drug develo...
Phosphorylated p38 MAP kinase expression by leucocytes is increased in allergic humans and associated with IgE responses.
Scandinavian journal of immunology
Nov 30, 2023
Mitogen-activated protein kinases (MAPK) activate cascades that regulate cell proliferation, differentiation and death. Phosphorylated (phos-)p38 MAPK is a cell-signalling pathway associated with Th2 cytokine responses, which is required for immunogl...
Untargeted metabolomic profiling in children identifies novel pathways in asthma and atopy.
The Journal of allergy and clinical immunology
Oct 29, 2023
BACKGROUND: Asthma and other atopic disorders can present with varying clinical phenotypes marked by differential metabolomic manifestations and enriched biological pathways.
Predicting the therapeutic efficacy of AIT for asthma using clinical characteristics, serum allergen detection metrics, and machine learning techniques.
Computers in biology and medicine
Sep 29, 2023
Bronchial asthma is a prevalent non-communicable disease among children. The study collected clinical data from 390 children aged 4-17 years with asthma, with or without rhinitis, who received allergen immunotherapy (AIT). Combining these data, this ...
Evaluating the Performance of Inclusive Growth Based on the BP Neural Network and Machine Learning Approach.
Computational intelligence and neuroscience
Jun 30, 2022
In this paper, we use the panel data of 281 cities in China from 2005 to 2020 for capturing the factors driving urban inclusive growth (IG). In doing this, we employ the BP neural network algorithm combined with the DEA model to measure the urban inc...
S. aureus and IgE-mediated diseases: pilot or copilot? A narrative review.
Expert review of clinical immunology
May 9, 2022
INTRODUCTION: is a major opportunistic pathogen that has been implicated in the pathogenesis of several chronic inflammatory diseases including bronchial asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), chronic spontaneous urticaria (CSU),...
Specific IgE and IgG4 Profiles of House Dust Mite Components in Allergen-Specific Immunotherapy.
Frontiers in immunology
Feb 7, 2022
BACKGROUND: Allergen immunotherapy (AIT) can induce immune tolerance to allergens by activating multiple mechanisms, including promoting IgG4 synthesis and blunting IgE production. However, the longitudinal data of sIgE and sIgG4 to allergen componen...
NIgPred: Class-Specific Antibody Prediction for Linear B-Cell Epitopes Based on Heterogeneous Features and Machine-Learning Approaches.
Viruses
Aug 3, 2021
Upon invasion by foreign pathogens, specific antibodies can identify specific foreign antigens and disable them. As a result of this ability, antibodies can help with vaccine production and food allergen detection in patients. Many studies have focus...
Demographic, Clinical, and Allergic Characteristics of Children with Eosinophilic Esophagitis in Isfahan, Iran.
Iranian journal of allergy, asthma, and immunology
Dec 3, 2018
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease isolated to the esophagus Food allergy is thought to play an important role in the pathophysiology of EOE. The aim of this study is to evaluate demographic features and sensitivity o...
Dynamic changes in specific anti-L-asparaginase antibodies generation during acute lymphoblastic leukemia treatment.
Pharmacological reports : PR
Nov 28, 2018
BACKGROUND: L-asparaginase (L-asp) remains one of the key components of acute lymphoblastic leukemia therapy. Immune reactions to the drug are associated with its diminished activity. The aim of the study was to determine the level of IgM, IgG and Ig...
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