Talaromydien a and talaroisocoumarin A, new metabolites from the marine-sourced fungus sp. ZZ1616.

Journal: Natural product research
Published Date: Jun 17, 2020

Abstract

New talaromydien A and talaroisocoumarin A (), together with nine known compounds (-), were isolated from a culture of the marine-derived sp. ZZ1616 in potato dextrose broth medium. Structures of the new compounds were elucidated based on their HRESIMS data, NMR spectroscopic analyses, the modified Mosher's method, ECD, C NMR and optical rotation calculations. Talaroisocoumarin A showed antimicrobial activities with MIC values of 36.0 μg/mL against methicillin-resistant , 32.0 μg/mL against , and 26.0 μg/mL against .

Authors

  • Mingzhu Ma
    Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.
  • Wenwen Yi
    Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.
  • Le Qin
    Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.
  • Xiao-Yuan Lian
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
  • Zhizhen Zhang
    Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.

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