Digital Biopsy with Fluorescence Confocal Microscope for Effective Real-time Diagnosis of Prostate Cancer: A Prospective, Comparative Study.

Journal: European urology oncology
Published Date: Sep 18, 2020

Abstract

BACKGROUND: A microscopic analysis of tissue is the gold standard for cancer detection. Hematoxylin-eosin (HE) for the reporting of prostate biopsy (PB) is conventionally based on fixation, processing, acquisition of glass slides, and analysis with an analog microscope by a local pathologist. Digitalization and real-time remote access to images could enhance the reporting process, and form the basis of artificial intelligence and machine learning. Fluorescence confocal microscopy (FCM), a novel optical technology, enables immediate digital image acquisition in an almost HE-like resolution without requiring conventional processing.

Authors

  • Bernardo Rocco
    Department of Urology, University of Central Florida College of Medicine and Global Robotics Institute, Florida Hospital-Celebration Health, Celebration, FL, USA.
  • Maria Chiara Sighinolfi
    Department of Urology. University of Modena and Reggio Emilia. Modena. Italy.
  • Marco Sandri
    University of Brescia, Data Methods and Systems Statistical Laboratory, Brescia, Italy.
  • Valentina Spandri
    School of Medicine and Surgery, University of Modena and Reggio Emilia, Modena, Italy.
  • Alessia Cimadamore
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
  • Metka Volavsek
    Department of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
  • Roberta Mazzucchelli
    Department of Pathology, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
  • Antonio Lopez-Beltran
    Department of Pathology and Surgery, Faculty of Medicine, Cordoba, Spain.
  • Ahmed Eissa
    Urology Department. Faculty of Medicine. Tanta University. Egypt.Department of Urology. University of Modena and Reggio Emilia. Modena. Italy.
  • Laura Bertoni
    Department of Human Anatomy, University of Modena and Reggio Emilia, Modena, Italy.
  • Paola Azzoni
    Department of Human Anatomy, University of Modena and Reggio Emilia, Modena, Italy.
  • Luca Reggiani Bonetti
    Department of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
  • Antonino Maiorana
    Department of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
  • Stefano Puliatti
    Urology Department, University of Modena and Reggio Emilia, Modena, Italy.
  • Salvatore Micali
    Department of Urology. University of Modena and Reggio Emilia. Modena. Italy.
  • Maurizio Paterlini
    Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy.
  • Andrea Iseppi
    Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense Modena, University of Modena and Reggio Emilia, Modena, Italy.
  • Francesco Rocco
    Columbus Clinic, Milan, Italy.
  • Giovanni Pellacani
    Facolta di Medicina et Chirugia, UNIMORE Iniversita Degli Studi di Modena e Reggio Emilia, Modena, Italy.
  • Johanna Chester
    Dermatology Department, University of Modena and Reggio Emilia, Modena, Italy.
  • Giampaolo Bianchi
    Dipartimento Chirurgico Medico Odontoiatrico e di Scienze Morfologiche con Interesse Trapiantologico, Universita degli Studi di Modena e Reggio Emilia , Modena, Italy.
  • Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy. Electronic address: r.montironi@univpm.it.

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