Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults.

Journal: Environmental health perspectives
PMID: 32930613

Abstract

BACKGROUND: Fetal exposure to maternal smoking during pregnancy is associated with the development of noncommunicable diseases in the offspring. Maternal smoking may induce such long-term effects through persistent changes in the DNA methylome, which therefore hold the potential to be used as a biomarker of this early life exposure. With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA methylation data and thereby generate a score for cigarette smoke exposure.

Authors

  • Sebastian Rauschert
    Telethon Kids Institute, University of Western Australia, Nedlands, Perth, Western Australia, Australia.
  • Phillip E Melton
    Centre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Australia.
  • Anni Heiskala
    Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Ville Karhunen
    Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu FI-90014, Finland.
  • Graham Burdge
    Institute of Developmental Sciences, University of Southampton, Faculty of Medicine, Southampton, UK.
  • Jeffrey M Craig
    Centre for Molecular and Medical Research, School of Medicine, Deakin University, Geelong, Victoria, Australia.
  • Keith M Godfrey
    MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
  • Karen Lillycrop
    Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, Hampshire, UK.
  • Trevor A Mori
    Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia.
  • Lawrence J Beilin
    Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia.
  • Wendy H Oddy
    Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
  • Craig Pennell
    School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
  • Marjo-Riitta Järvelin
    Center for Life Course Health Research, University of Oulu, Oulu, Finland.
  • Sylvain Sebert
    Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu FI-90014, Finland.
  • Rae-Chi Huang
    Telethon Kids Institute, University of Western Australia, Nedlands, Perth, Western Australia, Australia.

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