How Does the Skeletal Oncology Research Group Algorithm's Prediction of 5-year Survival in Patients with Chondrosarcoma Perform on International Validation?

Journal: Clinical orthopaedics and related research
PMID: 32433107

Abstract

BACKGROUND: The Skeletal Oncology Research Group (SORG) machine learning algorithm for predicting survival in patients with chondrosarcoma was developed using data from the Surveillance, Epidemiology, and End Results (SEER) registry. This algorithm was externally validated on a dataset of patients from the United States in an earlier study, where it demonstrated generally good performance but overestimated 5-year survival. In addition, this algorithm has not yet been validated in patients outside the United States; doing so would be important because external validation is necessary as algorithm performance may be misleading when applied in different populations.

Authors

  • Michiel E R Bongers
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Aditya V Karhade
    Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Elisabetta Setola
    E. Setola, E. Palmerini, Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Marco Gambarotti
    M. Gambarotti, Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Olivier Q Groot
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA.
  • Kivilcim E Erdoğan
    K. E. Erdoğan, Department of Pathology, Cukurova University, Medical Faculty, Adana, Turkey.
  • Piero Picci
    P. Picci, Italian Sarcoma Group , Bologna, Italy.
  • Davide M Donati
    D. M. Donati, Orthopaedic Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
  • Joseph H Schwab
    Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: jhschwab@mgh.harvard.edu.
  • Emanuela Palmerini
    E. Setola, E. Palmerini, Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

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