Journal of cancer research and clinical oncology
Jan 8, 2026
PURPOSE: High-dose ifosfamide (HD-IFO) remains an effective regimen for advanced bone and soft tissue sarcomas, but predictors of long-term benefit are poorly defined. This study evaluated clinical outcomes and prognostic factors using machine learni...
BACKGROUND: Despite decades of therapeutic development, osteosarcoma survival remains poor. Although berberine (BBR) shows anti-tumor activity, its efficacy is limited. We addressed this through structural modification and machine learning-guided dis...
. Quantitative assessment of treatment response in advanced prostate cancer (APC) with bone metastases remains an unmet clinical need. Whole-body diffusion-weighted MRI (WB-DWI) provides two response biomarkers: total diffusion volume (TDV) and globa...
Emerging evidence suggests that post-translational modifications (PTMs) contribute to osteosarcoma pathogenesis, yet their exact molecular roles require further elucidation. Using the AddModuleScore method, we classified tumor cells on the basis of P...
Bone cancer pain (BCP) is a complex condition that severely affects patients' quality of life, and its treatment remains challenging. Astaxanthin, a potent antioxidant with anti-inflammatory and neuroprotective effects, and celecoxib, a selective COX...
Chemical graph theory and topological indices are key tools in the study of molecular structures and their properties. This research explores anticancer drugs using neighborhood degree-based topological indices and compares their efficacy through reg...
An enchondroma is a benign neoplasm of mature hyaline cartilage that proliferates from the medullary cavity toward the cortical bone. This results in the formation of a significant endogenous mass within the medullary cavity. Although enchondromas ar...
Artificial intelligence (AI) has garnered increasing attention in the medical field. As the core technology of AI, deep learning (DL) has been extensively applied to the imaging-based screening of orthopedic diseases, primarily including image classi...
Bone metastasis (BM) is common in high-grade lung neuroendocrine tumors (NETs). This study aimed to use multiple machine learning algorithms to exploring the significant factors associated with synchronous BM in these patients. Patients diagnosed wit...
BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor, with high invasiveness and metastatic potential and a poor prognosis in patients with metastatic cancer. Despite the rapid advancements in genomics in recent years that provide...
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