Interpretation of cluster structures in pain-related phenotype data using explainable artificial intelligence (XAI).

Journal: European journal of pain (London, England)
Published Date:

Abstract

BACKGROUND: In pain research and clinics, it is common practice to subgroup subjects according to shared pain characteristics. This is often achieved by computer-aided clustering. In response to a recent EU recommendation that computer-aided decision making should be transparent, we propose an approach that uses machine learning to provide (1) an understandable interpretation of a cluster structure to (2) enable a transparent decision process about why a person concerned is placed in a particular cluster.

Authors

  • Jörn Lötsch
    Institute of Clinical Pharmacology, Goethe - University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
  • Sebastian Malkusch
    Institute of Clinical Pharmacology, Goethe - University, Frankfurt am Main, Germany.