Selecting Children with Vesicoureteral Reflux Who are Most Likely to Benefit from Antibiotic Prophylaxis: Application of Machine Learning to RIVUR.

Journal: The Journal of urology
PMID: 33289598

Abstract

PURPOSE: Continuous antibiotic prophylaxis reduces the risk of recurrent urinary tract infection by 50% in children with vesicoureteral reflux. However, there may be subgroups in whom continuous antibiotic prophylaxis could be used more selectively. We sought to develop a machine learning model to identify such subgroups.

Authors

  • Dimitris Bertsimas
    Dimitris Bertsimas, Jack Dunn, Colin Pawlowski, John Silberholz, Alexander Weinstein, and Ying Daisy Zhuo, Massachusetts Institute of Technology, Cambridge; Eddy Chen, Massachusetts General Hospital Cancer Center; Harvard Medical School; Aymen A. Elfiky, Dana-Farber Cancer Institute; Brigham and Women's Hospital; Harvard Medical School, Boston, MA.
  • Michael Li
    Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY.
  • Carlos Estrada
    Department of Urology, Boston Children's Hospital (Advanced Analytics Group of Pediatric Urology), Boston, Massachusetts.
  • Caleb Nelson
    Department of Urology, Boston Children's Hospital (Advanced Analytics Group of Pediatric Urology), Boston, Massachusetts.
  • Hsin-Hsiao Scott Wang
    Department of Urology, Boston Children's Hospital (Advanced Analytics Group of Pediatric Urology), Boston, Massachusetts.

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