AIMC Topic: Patient Selection

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Computational Framework for Structuring and Analyzing Clinical Trial Criteria for AI-Guided Fine-grained Matching.

Journal of medical systems
While artificial intelligence (AI) has demonstrated potential in automating clinical trial matching, most existing solutions rely on high-level structured data or oversimplified criteria. This study introduces a framework to structure and analyze eli...

Looking back to move forward: can historical clinical trial data and machine learning drive change in participant recruitment in anticipation of future value assessments?

Trials
Drug development is an expensive endeavor, with costs averaging $879.3 million and only 14.3% of them ultimately securing regulatory approval. One fundamental challenge is ensuring that the enrolled patient population in a clinical trial accurately r...

Social Media Recruitment in Indigenous and Native American Populations: Challenges in the AI Age.

JMIR public health and surveillance
Using social media recruitment for public health research presents both opportunities and challenges. Despite its increased use, few studies have detailed the practical issues, challenges encountered, and alternative strategies available for social m...

Detecting Conversation Topics in Recruitment Calls of African American Participants to the All of Us Research Program Using Machine Learning: Model Development and Validation Study.

JMIR formative research
BACKGROUND: Advancements in science and technology can exacerbate health disparities, particularly when there is a lack of diversity in clinical research, which limits the benefits of innovations for underrepresented communities. Programs like the Al...

Predicting Morbidity and Mortality After Transjugular Intrahepatic Portosystemic Shunt Placement: A Review of Existing Models and Future Directions.

Techniques in vascular and interventional radiology
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention in the management of portal hypertension and its complications, such as variceal bleeding, hepatic hydrothorax, and refractory ascites. TIPS has historically been ...

Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning.

Science advances
Therapeutic clinical trial enrollment does not match glioma incidence across demographics. Traditional statistical methods have identified independent predictors of trial enrollment; however, our understanding of the interactions between these factor...

Enriching patient populations in ICU trials: reducing heterogeneity through machine learning.

Current opinion in critical care
PURPOSE OF REVIEW: Despite the pivotal role of randomized controlled trials (RCTs) in critical care research, many have failed to demonstrate significant benefits, particularly in nutrition interventions. This review highlights how patient heterogene...

Accuracy of machine learning in identifying candidates for total knee arthroplasty (TKA) surgery: a systematic review and meta-analysis.

European journal of medical research
BACKGROUND: The application of machine learning (ML) in predicting the requirement for total knee arthroplasty (TKA) at knee osteoarthritis (KOA) patients has been acknowledged. Nonetheless, the variables employed in the development of ML models are ...

Large language models for automating clinical trial matching.

Current opinion in urology
PURPOSE OF REVIEW: The uses of generative artificial intelligence (GAI) technologies in medicine are expanding, with the use of large language models (LLMs) for matching patients to clinical trials of particular interest. This review provides an over...

Utilising Natural Language Processing to Identify Brain Tumor Patients for Clinical Trials: Development and Initial Evaluation.

World neurosurgery
BACKGROUND: Identifying patients eligible for clinical trials through eligibility screening is time and resource-intensive. Natural Language Processing (NLP) models may enhance clinical trial screening by extracting data from Electronic Health Record...