Forecasting influenza activity using machine-learned mobility map.

Journal: Nature communications
PMID:

Abstract

Human mobility is a primary driver of infectious disease spread. However, existing data is limited in availability, coverage, granularity, and timeliness. Data-driven forecasts of disease dynamics are crucial for decision-making by health officials and private citizens alike. In this work, we focus on a machine-learned anonymized mobility map (hereon referred to as AMM) aggregated over hundreds of millions of smartphones and evaluate its utility in forecasting epidemics. We factor AMM into a metapopulation model to retrospectively forecast influenza in the USA and Australia. We show that the AMM model performs on-par with those based on commuter surveys, which are sparsely available and expensive. We also compare it with gravity and radiation based models of mobility, and find that the radiation model's performance is quite similar to AMM and commuter flows. Additionally, we demonstrate our model's ability to predict disease spread even across state boundaries. Our work contributes towards developing timely infectious disease forecasting at a global scale using human mobility datasets expanding their applications in the area of infectious disease epidemiology.

Authors

  • Srinivasan Venkatramanan
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.
  • Adam Sadilek
    1Google Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043 USA.
  • Arindam Fadikar
    Argonne National Laboratory, Lemont, IL, USA.
  • Christopher L Barrett
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.
  • Matthew Biggerstaff
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Jiangzhuo Chen
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.
  • Xerxes Dotiwalla
    Google Inc., Mountain View, CA, USA.
  • Paul Eastham
    Google Inc., Mountain View, CA, USA.
  • Bryant Gipson
    Google Inc., Mountain View, CA, USA.
  • Dave Higdon
    Department of Statistics, Virginia Tech, Blacksburg, VA, USA.
  • Onur Kucuktunc
    Google Inc., Mountain View, CA, USA.
  • Allison Lieber
    Google Inc., Mountain View, CA, USA.
  • Bryan L Lewis
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.
  • Zane Reynolds
    Torc Robotics, Blacksburg, VA, USA.
  • Anil K Vullikanti
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.
  • Lijing Wang
    School of Aeronautic Science and Engineering, Beihang University, Beijing, China.
  • Madhav Marathe
    Biocomplexity Institute and Initiative, University of Virginia, Charlottesville, VA, USA.