Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment. We investigated differences in the surface proteome...
BACKGROUND: H3 influenza A viruses (IAV) have been shown to frequently cross the species barrier which can be an important factor in sustained transmission and spread. Machine learning methods have been widely explored for host prediction of IAV usin...
Lateral flow immunoassays (LFIAs) are widely used point-of-care (POC) diagnostic tools, but their limited sensitivity can hinder reliable diagnoses. To address this limitation, we developed a novel POC diagnostic platform for the highly sensitive det...
Proceedings of the National Academy of Sciences of the United States of America
Oct 24, 2025
Accurate forecasts of disease outbreaks are critical for effective public health responses, management of healthcare surge capacity, and communication of public risk. There are a growing number of powerful forecasting methods that fall into two broad...
Epidemiological data is often analyzed without fully accounting for the uncertainties that are key to understanding the nuances of the dataset. While traditional approaches like the SIR mathematical model provide valuable insights, our study aims to ...
Rapid point of care tests for respiratory infections are associated with high rates of false negative results which can drive empiric, and potentially inappropriate, antibiotic use. Because infectious pathogens alter VOC composition, unique VOC signa...
BACKGROUND: Viral respiratory infections (VRTIs) caused by influenza (Flu) and COVID-19 pose significant global health challenges. Clinical outcomes are further exacerbated by infections with hospital acquired drug resistant pathogens (DRPs).
Influenza A viruses (IAVs) have historically posed significant public health threats, causing severe pandemics. Viral host specificity is typically constrained by host barriers, limiting the range of species that can be infected. However, these barri...
The increasing zoonotic potential of highly pathogenic avian influenza (HPAI) H5N1 poses a growing threat to global public health. This review examines the molecular and evolutionary mechanisms facilitating H5N1 adaptation in mammalian hosts, focusin...
BACKGROUND: The seasonal influenza epidemic poses a persistent and severe threat to global public health. Web-based search data are recognized as a valuable source for forecasting influenza or other respiratory tract infection epidemics. Current infl...
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