Machine Learning-Based Prediction of COVID-19 Severity and Progression to Critical Illness Using CT Imaging and Clinical Data.

Journal: Korean journal of radiology
Published Date:

Abstract

OBJECTIVE: To develop a machine learning (ML) pipeline based on radiomics to predict Coronavirus Disease 2019 (COVID-19) severity and the future deterioration to critical illness using CT and clinical variables.

Authors

  • Subhanik Purkayastha
    Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  • Yanhe Xiao
    Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.
  • Zhicheng Jiao
  • Rujapa Thepumnoeysuk
    Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
  • Kasey Halsey
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Jing Wu
    School of Pharmaceutical Science, Jiangnan University, Wuxi, 214122, Jiangsu, China.
  • Thi My Linh Tran
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Ben Hsieh
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Ji Whae Choi
    From the Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China (H.X.B., Z.X., D.C.W., W.H.L.); Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI (H.X.B., B.H., K.H., I.P., M.K.A.); Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa (R.W.); Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology. Massachusetts General Hospital, Boston, Mass (K.C.); Warren Alpert Medical School at Brown University, Providence, RI (H.X.B., K.H., T.M.L.T., J.W.C., I.P.); Department of Radiology, Yongzhou Central Hospital, Yongzhou, China (L.B.S.); Department of Radiology, Changde Second People's Hospital, Changde, China (J.M.); Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, China (X.L.J.); Department of Radiology, Loudi Central Hospital, Loudi, China (Q.H.Z.); Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, China (P.F.H.); Department of Radiology, Zhuzhou Central Hospital, Zhuzhou, China (Y.H.L.); Department of Radiology, Yiyang City Center Hospital, Yiyang, China (F.X.F.); Department of Radiology, Brigham and Women's Hospital, Boston, Mass (R.Y.H.); Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (R.S.); and Department of Radiology, The First Hospital of Changsha, Changsha, China (Q.Z.Y.).
  • Dongcui Wang
    Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008; Postdoctoral Research Workstation of Clinical Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
  • Martin Vallières
    Medical Physics Unit, McGill University and Cedars Cancer Center, 1001 Décarie Blvd, Montréal, QC, H4A 3J1, Canada.
  • Robin Wang
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Scott Collins
    Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
  • Xue Feng
    Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia.
  • Michael Feldman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine Philadelphia, PA, United States; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
  • Paul J Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
  • Michael Atalay
    Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
  • Ronnie Sebro
    Department of Radiology, University of Pennsylvania, 3737 Market Street, Philadelphia, PA, 19104, USA. Ronnie.sebro@uphs.upenn.edu.
  • Li Yang
    Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Yong Fan
    CPB/ECMO Children's Hospital, Zhejiang University School of Medicine, 310052 Hangzhou, Zhejiang, China.
  • Wei Hua Liao
    Department of Radiology, Xiangya Hospital, Central South University, Changsha, China. owenliao@csu.edu.cn.
  • Harrison X Bai
    Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.