Establishing a consensus for the hallmarks of cancer based on gene ontology and pathway annotations.
Journal:
BMC bioinformatics
Published Date:
Apr 6, 2021
Abstract
BACKGROUND: The hallmarks of cancer provide a highly cited and well-used conceptual framework for describing the processes involved in cancer cell development and tumourigenesis. However, methods for translating these high-level concepts into data-level associations between hallmarks and genes (for high throughput analysis), vary widely between studies. The examination of different strategies to associate and map cancer hallmarks reveals significant differences, but also consensus.