Predicting Infarct Core From Computed Tomography Perfusion in Acute Ischemia With Machine Learning: Lessons From the ISLES Challenge.

Journal: Stroke
Published Date:

Abstract

BACKGROUND AND PURPOSE: The ISLES challenge (Ischemic Stroke Lesion Segmentation) enables globally diverse teams to compete to develop advanced tools for stroke lesion analysis with machine learning. Detection of irreversibly damaged tissue on computed tomography perfusion (CTP) is often necessary to determine eligibility for late-time-window thrombectomy. Therefore, the aim of ISLES-2018 was to segment infarcted tissue on CTP based on diffusion-weighted imaging as a reference standard.

Authors

  • Arsany Hakim
    University Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, Inselspital (A.H., R.W.), University of Bern, Switzerland.
  • Soren Christensen
    1 Stanford Stroke Center, Stanford University Medical Center, Stanford, CA, USA.
  • Stefan Winzeck
    University Division of Anaesthesia, Department of Medicine, University of Cambridge, United Kingdom (S.W.).
  • Maarten G Lansberg
    1 Stanford Stroke Center, Stanford University Medical Center, Stanford, CA, USA.
  • Mark W Parsons
    5 Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia.
  • Christian Lucas
    Institute of Medical Informatics, University of Lübeck, Germany (C.L.).
  • David Robben
    Medical Imaging Research Center (MIRC), KU Leuven, Leuven, Belgium; Medical Image Computing (MIC), ESAT-PSI, Department of Electrical Engineering, KU Leuven, Leuven, Belgium; Icometrix, Leuven, Belgium. Electronic address: david.robben@kuleuven.be.
  • Roland Wiest
    Institute for Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland.
  • Mauricio Reyes
    Center for Artificial Intelligence in Medicine, University of Bern, Bern, Switzerland.
  • Greg Zaharchuk
    Stanford University, Stanford CA 94305, USA.