Clinically Applicable Segmentation of Head and Neck Anatomy for Radiotherapy: Deep Learning Algorithm Development and Validation Study.

Journal: Journal of medical Internet research
Published Date: Jul 12, 2021

Abstract

BACKGROUND: Over half a million individuals are diagnosed with head and neck cancer each year globally. Radiotherapy is an important curative treatment for this disease, but it requires manual time to delineate radiosensitive organs at risk. This planning process can delay treatment while also introducing interoperator variability, resulting in downstream radiation dose differences. Although auto-segmentation algorithms offer a potentially time-saving solution, the challenges in defining, quantifying, and achieving expert performance remain.

Authors

  • Stanislav Nikolov
    DeepMind, London, UK.
  • Sam Blackwell
    DeepMind, London, UK.
  • Alexei Zverovitch
    Google Health, London, United Kingdom.
  • Ruheena Mendes
    University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • Michelle Livne
    CLAIM - Charité Lab for Artificial Intelligence in Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Jeffrey De Fauw
    DeepMind, London, EC4A 3TW, UK.
  • Yojan Patel
    Google Health, London, United Kingdom.
  • Clemens Meyer
    DeepMind, London, UK.
  • Harry Askham
    DeepMind, London, UK.
  • Bernadino Romera-Paredes
    DeepMind, London, United Kingdom.
  • Christopher Kelly
    Google Health, London, UK.
  • Alan Karthikesalingam
    Department of Outcomes Research, St George's Vascular Institute, London, SW17 0QT, United Kingdom.
  • Carlton Chu
    DeepMind, London, EC4A 3TW, UK.
  • Dawn Carnell
    University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • Cheng Boon
    Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, United Kingdom.
  • Derek D'Souza
    University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • Syed Ali Moinuddin
    University College London Hospitals NHS Foundation Trust, London, United Kingdom.
  • Bethany Garie
    DeepMind, London, United Kingdom.
  • Yasmin McQuinlan
    DeepMind, London, United Kingdom.
  • Sarah Ireland
    DeepMind, London, United Kingdom.
  • Kiarna Hampton
    DeepMind, London, United Kingdom.
  • Krystle Fuller
    DeepMind, London, United Kingdom.
  • Hugh Montgomery
    Institute of Sport, Exercise and Health, London, W1T 7HA, UK.
  • Geraint Rees
    Institute of Neurology, University College London, London, WC1N 3BG, UK.
  • Mustafa Suleyman
    DeepMind, London, UK.
  • Trevor Back
    DeepMind, London, EC4A 3TW, UK.
  • Cían Owen Hughes
    Google Health, London, United Kingdom.
  • Joseph R Ledsam
    DeepMind, London, UK.
  • Olaf Ronneberger
    DeepMind, London, EC4A 3TW, UK.

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