Ceftolozane-tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study.

Journal: European journal of hospital pharmacy : science and practice
PMID: 32296512

Abstract

OBJECTIVES: Published in vitro stability data for ceftolozane-tazobactam supports intermittent short duration infusions. This method of delivery is not feasible for many outpatient antimicrobial therapy services that provide only one or two visits per day. This study aimed to assess time, temperature and concentration-dependent stability of ceftolozane-tazobactam in an elastomeric infusion device for continuous infusion across clinically relevant ranges encountered in outpatient antimicrobial therapy.

Authors

  • Edward Raby
    Infectious Diseases Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
  • Saiyuri Naicker
    University Of Queensland Centre for Clinical Research, University of Queensland, Herston, Queensland, Australia.
  • Fekade Bruck Sime
    University Of Queensland Centre for Clinical Research, University of Queensland, Herston, Queensland, Australia.
  • Laurens Manning
    Infectious Diseases Department, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
  • Steven C Wallis
    University Of Queensland Centre for Clinical Research, University of Queensland, Herston, Queensland, Australia.
  • Saurabh Pandey
    University Of Queensland Centre for Clinical Research, University of Queensland, Herston, Queensland, Australia.
  • Jason A Roberts
    Centre for Translational Anti-infective Pharmacodynamics, Pharmacy Australia Centre of Excellence, Brisbane, Queensland, Australia.

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