AIMC Topic: Drug Stability
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Machine learning strengthened formulation design of pharmaceutical suspensions.
International journal of pharmaceutics
Nov 19, 2024
Many different formulation strategies have been investigated to oppose suboptimal treatment of long-term or chronic conditions, one of which are the nano- and microsuspensions prepared as long-acting injectables to prolong the release of an active ph...
Particle formation in response to different protein formulations and containers: Insights from machine learning analysis of particle images.
Journal of pharmaceutical sciences
Oct 9, 2024
Subvisible particle count is a biotherapeutics stability indicator widely used by pharmaceutical industries. A variety of stresses that biotherapeutics are exposed to during development can impact particle morphology. By classifying particle morpholo...
Reliable stability prediction to manage research or marketed vaccines and pharmaceutical products. "Avoid any doubt for the end-user of vaccine compliance at time of administration".
International journal of pharmaceutics
Feb 24, 2022
A major challenge for the pharmaceutical/vaccine industry is to anticipate and test/control product stability, regardless of the time/temperature profile of the product, from release to administration. Current empirical stability protocols performed ...
Development of LC-MS/MS determination method and backpropagation artificial neural networks pharmacokinetic model of febuxostat in healthy subjects.
Journal of clinical pharmacy and therapeutics
Nov 17, 2020
WHAT IS KNOWN AND OBJECTIVE: Febuxostat is a well-known drug for treating hyperuricemia and gout. The published methods for determination of febuxostat in human plasma might be unsuitable for high-throughput determination and widespread application. ...
Application of machine learning to predict monomer retention of therapeutic proteins after long term storage.
International journal of pharmaceutics
Jan 15, 2020
An important aspect of initial developability assessments as well formulation development and selection of therapeutic proteins is the evaluation of data obtained under accelerated stress condition, i.e. at elevated temperatures. We propose the appli...
Ceftolozane-tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study.
European journal of hospital pharmacy : science and practice
Dec 16, 2019
OBJECTIVES: Published in vitro stability data for ceftolozane-tazobactam supports intermittent short duration infusions. This method of delivery is not feasible for many outpatient antimicrobial therapy services that provide only one or two visits pe...
Physicochemical stability of an admixture of lidocaine and ketamine in polypropylene syringe used in opioid-free anaesthesia.
European journal of hospital pharmacy : science and practice
Oct 18, 2019
OBJECTIVES: Opioid-free anaesthesia is a treatment strategy of pain management based on the use of drugs such as lidocaine, ketamine and dexmedetomidine that do not interact significantly with opioid receptors. In particular, these drugs are used by ...
DeepChemStable: Chemical Stability Prediction with an Attention-Based Graph Convolution Network.
Journal of chemical information and modeling
Feb 21, 2019
In the drug discovery process, unstable compounds in storage can lead to false positive or false negative bioassay conclusions. Prediction of the chemical stability of a compound by de novo methods is complex. Chemical instability prediction is commo...
Investigation of meropenem stability after reconstitution: the influence of buffering and challenges to meet the NHS Yellow Cover Document compliance for continuous infusions in an outpatient setting.
European journal of hospital pharmacy : science and practice
Jan 13, 2019
OBJECTIVES: To determine the influence of different buffers, pH and meropenem concentrations on the degradation rates of meropenem in aqueous solution during storage at 32°C, with the aim of developing a formulation suitable for 24-hour infusion in a...
Validation of a UPLC-PDA method to study the content and stability of 5-chloro 8-hydroxyquinoline and 5,7-dichloro 8-hydroxyquinoline in medicated feed used in swine farming.
Journal of pharmaceutical and biomedical analysis
Dec 21, 2018
A new, rapid, simple and specific method to determine 5-chloro 8-hydroxyquinoline (5-HQ) and 5,7-dichloro 8-hydroxyquinoline (5,7-HQ) stability in swine feed was optimized and validated. A system consisting of an ACQUITY UPLC BEH C column (1.7 μm, 2....
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