Electronic phenotyping of health outcomes of interest using a linked claims-electronic health record database: Findings from a machine learning pilot project.

Journal: Journal of the American Medical Informatics Association : JAMIA
Published Date:

Abstract

OBJECTIVE: Claims-based algorithms are used in the Food and Drug Administration Sentinel Active Risk Identification and Analysis System to identify occurrences of health outcomes of interest (HOIs) for medical product safety assessment. This project aimed to apply machine learning classification techniques to demonstrate the feasibility of developing a claims-based algorithm to predict an HOI in structured electronic health record (EHR) data.

Authors

  • Teresa B Gibson
    Jessica C. Young is with the Cecil. G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill. Cory Pack, Teresa B. Gibson, Frank Yoon, Debra E. Irwin, and Shalu Shiv are with IBM Watson Health, Bethesda, MD. Toska Cooper and Nabarun Dasgupta are with the Injury Prevention Research Center, University of North Carolina, Chapel Hill.
  • Michael D Nguyen
    Food and Drug Administration, Silver Spring, Maryland, USA.
  • Timothy Burrell
    Government Health and Human Services, IBM Watson Health, Bethesda, Maryland, USA.
  • Frank Yoon
    Jessica C. Young is with the Cecil. G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill. Cory Pack, Teresa B. Gibson, Frank Yoon, Debra E. Irwin, and Shalu Shiv are with IBM Watson Health, Bethesda, MD. Toska Cooper and Nabarun Dasgupta are with the Injury Prevention Research Center, University of North Carolina, Chapel Hill.
  • Jenna Wong
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada.
  • Sai Dharmarajan
    Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
  • Rita Ouellet-Hellstrom
    Division of Epidemiology II, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
  • Wei Hua
    Food and Drug Administration, Silver Spring, Maryland, USA.
  • Yong Ma
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
  • Elande Baro
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
  • Sarah Bloemers
    Government Health and Human Services, IBM Watson Health, Bethesda, Maryland, USA.
  • Cory Pack
    Jessica C. Young is with the Cecil. G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill. Cory Pack, Teresa B. Gibson, Frank Yoon, Debra E. Irwin, and Shalu Shiv are with IBM Watson Health, Bethesda, MD. Toska Cooper and Nabarun Dasgupta are with the Injury Prevention Research Center, University of North Carolina, Chapel Hill.
  • Adee Kennedy
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Sengwee Toh
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts, USA.
  • Robert Ball
    Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States.