Nasopharyngeal metabolomics and machine learning approach for the diagnosis of influenza.

Journal: EBioMedicine
PMID:

Abstract

BACKGROUND: Respiratory virus infections are significant causes of morbidity and mortality, and may induce host metabolite alterations by infecting respiratory epithelial cells. We investigated the use of liquid chromatography quadrupole time-of-flight mass spectrometry (LC/Q-TOF) combined with machine learning for the diagnosis of influenza infection.

Authors

  • Catherine A Hogan
    Dept. of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Pranav Rajpurkar
    Harvard Medical School, Department of Biomedical Informatics, Cambridge, MA, 02115, US.
  • Hari Sowrirajan
    Stanford Computer Science Department, Stanford University, Stanford, CA 94305, USA.
  • Nicholas A Phillips
    Stanford Computer Science Department, Stanford University, Stanford, CA 94305, USA.
  • Anthony T Le
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Manhong Wu
    Stanford Department of Anesthesiology, Stanford University, Stanford, CA 94305, USA.
  • Natasha Garamani
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Malaya K Sahoo
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Mona L Wood
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Clinical Virology Laboratory, Stanford Health Care, Palo Alto, CA 94304, USA.
  • ChunHong Huang
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Andrew Y Ng
  • Justin Mak
    Stanford Biochemical Genetics Laboratory, Stanford Health Care, Palo Alto, CA 94304, USA.
  • Tina M Cowan
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Biochemical Genetics Laboratory, Stanford Health Care, Palo Alto, CA 94304, USA.
  • Benjamin A Pinsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Clinical Virology Laboratory, Stanford Health Care, Palo Alto, CA 94304, USA; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.