Pathogenic (PEC) strains are important pathogens that causes a variety of infectious diseases in humans. Traditional bacterial culture and biochemical identification methods are time-consuming and lack specificity, making rapid and accurate diagnosi...
Accurate and accessible molecular diagnostics are critical for early disease detection, infection control, and personalized medicine. Digital nucleic acid testing offers absolute quantification by isolating individual amplification events into discre...
is a globally distributed intracellular parasite, with felids serving as its definitive hosts and playing a central role in environmental contamination through oocyst shedding. Accurate and timely diagnosis in cats is critical for interrupting trans...
Respiratory viral infections pose a significant global public health challenge, partly due to the difficulty in rapidly and accurately distinguishing between viruses with similar symptoms at the point of care, hindering timely and appropriate treatme...
Digital nucleic acid amplification testing (dNAAT)-including digital PCR and isothermal techniques-has transformed precision diagnostics by enabling single-molecule quantification. However, its widespread adoption in point-of-care testing (POCT) rema...
Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, osteomyelitis, septic arthritis, and skin infection. The Centers for Disease Control and Prevention (C...
The tissues-of-origin of circulating cell-free DNA (cfDNA) holds great promise for non-invasive diagnosing cancers, monitoring allograft rejection, and prenatal testing. Many features for inferring the tissues-of-origin of cfDNAs are being revealed f...
Bladder cancer is a common type of urological cancer with high recurrence and mortality rates. Currently, it is diagnosed and monitored using minimal invasive cystoscopies and biopsies. Urinary cytology, the most widely accepted noninvasive and more ...
Frontiers in cellular and infection microbiology
Jan 16, 2025
BACKGROUND: Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due to different ddPCR platforms with dis...
Nucleic-acid biosensors have emerged as useful tools for on-farm detection of foodborne pathogens on fresh produce. Such tools are specifically designed to be user-friendly so that a producer can operate them with minimal training and in a few simple...
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