Whole brain segmentation with full volume neural network.

Journal: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Published Date:

Abstract

Whole brain segmentation is an important neuroimaging task that segments the whole brain volume into anatomically labeled regions-of-interest. Convolutional neural networks have demonstrated good performance in this task. Existing solutions, usually segment the brain image by classifying the voxels, or labeling the slices or the sub-volumes separately. Their representation learning is based on parts of the whole volume whereas their labeling result is produced by aggregation of partial segmentation. Learning and inference with incomplete information could lead to sub-optimal final segmentation result. To address these issues, we propose to adopt a full volume framework, which feeds the full volume brain image into the segmentation network and directly outputs the segmentation result for the whole brain volume. The framework makes use of complete information in each volume and can be implemented easily. An effective instance in this framework is given subsequently. We adopt the 3D high-resolution network (HRNet) for learning spatially fine-grained representations and the mixed precision training scheme for memory-efficient training. Extensive experiment results on a publicly available 3D MRI brain dataset show that our proposed model advances the state-of-the-art methods in terms of segmentation performance.

Authors

  • Yeshu Li
    Department of Computer Science, University of Illinois at Chicago, Chicago, IL 60607, United States. Electronic address: yli299@uic.edu.
  • Jonathan Cui
    Vacaville Christian Schools, Vacaville, CA 95687, United States. Electronic address: jonathancui03@gmail.com.
  • Yilun Sheng
    Institute for Interdisciplinary Information Sciences, Tsinghua University, Beijing 100084, China; Microsoft Research, Beijing 100080, China. Electronic address: ridic2651@gmail.com.
  • Xiao Liang
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Beijing Laboratory for Food Quality and Safety, Beijing, 100193, People's Republic of China; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, People's Republic of China.
  • Jingdong Wang
  • Eric I-Chao Chang
    Microsoft Research Asia, Beijing, China. eric.chang@microsoft.com.
  • Yan Xu
    Department of Nephrology, Suzhou Ninth People's Hospital, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, China.