Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS.

Journal: Neuropathology and applied neurobiology
PMID: 34595747

Abstract

AIMS: Although morphological attributes of cells and their substructures are recognised readouts of physiological or pathophysiological states, these have been relatively understudied in amyotrophic lateral sclerosis (ALS) research.

Authors

  • Colombine Verzat
    Genomics and Health Informatics Group, Idiap Research Institute, Martigny, Switzerland.
  • Jasmine Harley
    Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, UK.
  • Rickie Patani
    Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, UK.
  • Raphaëlle Luisier
    Genomics and Health Informatics Group, Idiap Research Institute, Martigny, Switzerland.

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