AIMC Topic: Motor Neurons

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Tailoring neuromuscular dynamics: A modeling framework for realistic sEMG simulation.

PloS one Jun 12, 2025
This study introduces an advanced computational model for simulating surface electromyography (sEMG) signals during muscle contractions. The model integrates five elements that simulate the chain of processes from motor intention to voltage variation...
Humans Computer Simulation Adult Models, Biological Muscle Contraction Isometric Contraction Motor Neurons Male Muscle, Skeletal Electromyography
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Conditional Generative Models for Simulation of EMG During Naturalistic Movements.

IEEE transactions on neural networks and learning systems May 2, 2025
Numerical models of electromyography (EMG) signals have provided a huge contribution to our fundamental understanding of human neurophysiology and remain a central pillar of motor neuroscience and the development of human-machine interfaces. However,...
Motor Neurons Muscle, Skeletal Algorithms Electromyography Humans Computer Simulation Movement Neural Networks, Computer
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5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression.

Neuromolecular medicine Apr 3, 2025
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to motor neuron degeneration, muscle weakness, and respiratory failure. Despite ongoing research, effective treatments for ALS are limited. This study aimed to...
Drug Repositioning Amyotrophic Lateral Sclerosis Gene Expression Profiling Motor Neurons Transcriptome Humans Gene Regulatory Networks Machine Learning Muscle, Skeletal
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Unsupervised Neural Decoding to Predict Dexterous Multi-Finger Flexion and Extension Forces.

IEEE journal of biomedical and health informatics Mar 6, 2025
Accurate control over individual fingers of robotic hands is essential for the progression of human-robot interactions. Accurate prediction of finger forces becomes imperative in this context. The state-of-the-art neural decoders can extract neural s...
Humans Female Young Adult Unsupervised Machine Learning Signal Processing, Computer-Assisted Electromyography Fingers Adult Male Muscle, Skeletal Motor Neurons
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Merging motoneuron and postural synergies in prosthetic hand design for natural bionic interfacing.

Science robotics Jan 15, 2025
Despite the advances in bionic reconstruction of missing limbs, the control of robotic limbs is still limited and, in most cases, not felt to be as natural by users. In this study, we introduce a control approach that combines robotic design based on...
Bionics Motor Neurons Hand Artificial Limbs Prosthesis Design Posture Muscle, Skeletal Robotics Algorithms Female Young Adult Male Middle Aged Adult Biomechanical Phenomena Humans
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Machine learning identified novel players in lipid metabolism, endosomal trafficking, and iron metabolism of the ALS spinal cord.

Scientific reports Jan 10, 2025
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Although genes causing familial cases have been identified, those of sporadic ALS, which occupies the majority of patients, are still elusive. In this s...
Endosomes Mitochondria Spinal Cord Motor Neurons Humans Amyotrophic Lateral Sclerosis Lipid Metabolism Machine Learning Iron
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A U-Net based partial convolutional time-domain separation model to identify motor units from surface electromyographic signals in real time.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology Dec 19, 2024
This study proposed a U-Net based partial convolutional time-domain model for a real-time high-density surface electromyography (HD-sEMG) decomposition. The model combines U-Net and a separation block containing partial convolution, aiming to efficie...
Neural Networks, Computer Female Humans Signal Processing, Computer-Assisted Electromyography Adult Motor Neurons Male Muscle, Skeletal
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Float like a butterfly, swim like a biohybrid neuromuscular robot.

Science robotics Sep 25, 2024
A butterfly-like robot swims using an electronic device to stimulate human-derived motor neurons and cardiac muscle cells.
Motor Neurons Equipment Design Biomimetics Myocytes, Cardiac Humans Animals Swimming Robotics
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Memristive Circuit Implementation of Caenorhabditis Elegans Mechanism for Neuromorphic Computing.

IEEE transactions on neural networks and learning systems Sep 3, 2024
To overcome the energy efficiency bottleneck of the von Neumann architecture and scaling limit of silicon transistors, an emerging but promising solution is neuromorphic computing, a new computing paradigm inspired by how biological neural networks h...
Nerve Net Caenorhabditis elegans Interneurons Motor Neurons Models, Neurological Robotics Neurons Locomotion Neural Networks, Computer Animals
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Digital Biomarker for Muscle Function Assessment Using Surface Electromyography With Electrical Stimulation and a Non-Invasive Wearable Device.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Aug 26, 2024
Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction. Individuals with unmanaged sarcopenia may experience adverse outcomes. P...
Muscle Contraction Adult Muscle, Skeletal Action Potentials Wavelet Analysis Biomarkers Male Sarcopenia Electric Stimulation Deep Learning Electromyography Middle Aged Humans Female Motor Neurons Wearable Electronic Devices Healthy Volunteers Neural Networks, Computer Young Adult Algorithms
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