Intentional deep overfit learning (IDOL): A novel deep learning strategy for adaptive radiation therapy.

Journal: Medical physics
Published Date:

Abstract

PURPOSE: Applications of deep learning (DL) are essential to realizing an effective adaptive radiotherapy (ART) workflow. Despite the promise demonstrated by DL approaches in several critical ART tasks, there remain unsolved challenges to achieve satisfactory generalizability of a trained model in a clinical setting. Foremost among these is the difficulty of collecting a task-specific training dataset with high-quality, consistent annotations for supervised learning applications. In this study, we propose a tailored DL framework for patient-specific performance that leverages the behavior of a model intentionally overfitted to a patient-specific training dataset augmented from the prior information available in an ART workflow-an approach we term Intentional Deep Overfit Learning (IDOL).

Authors

  • Jaehee Chun
    Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
  • Justin C Park
    Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
  • Sven Olberg
    Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
  • You Zhang
    Medical Artificial Intelligence and Automation (MAIA) Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Dan Nguyen
    University of Massachusetts Chan Medical School, Worcester, Massachusetts.
  • Jing Wang
    Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing, China.
  • Jin Sung Kim
    Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
  • Steve Jiang